Biosignaling Ye-Guang Chen
Biosignaling Ye-Guang Chen
General introduction Ion channels G-protein coupled receptors Second messengers Tyrosine kinase receptors From plasma membrane to the nucleus Regulation of gene expression Cytokine signaling Cell cycle Apoptosis Cell signaling and diseases
General introduction Ion channels G-protein coupled receptors Second messengers Tyrosine kinase receptors From plasma membrane to the nucleus: Regulation of gene expression Cytokine signaling Cell cycle Apoptosis Cell signaling and diseases
General introduction Ion channels G-protein coupled receptors Second messengers Tyrosine kinase receptors From plasma membrane to the nucleus Regulation of gene expression Cytokine signaling Cell cycle Apoptosis Cell signaling and diseases
General introduction Ion channels G-protein coupled receptors Second messengers Tyrosine kinase receptors From plasma membrane to the nucleus: Regulation of gene expression Cytokine signaling Cell cycle Apoptosis Cell signaling and diseases
table 13-1 Some Signals to Which Cells Respond Antigens Cell surface glycoproteins/oligosaccharides Developmental signals Extracellular matrix components Growth factors Hormones Light Mechanical touch Neurotransmitters Odorants Pheromones Tastants
Four features of signal transducing systems Part ll Structure and Catalysis (a)Specificity (c)Desensitization/Adaptation Signal molecule fits Receptor activation triggers binding site on its feedback circuit that shuts complementary receptor; off the receptor or removes Receptor other signals do not fit Receptor it from the cell surface Effect b)Amplification (d) Integration When enzymes activate When two signals have Signal 1 Signal 2 enzymes, the number of opposite effects on a affected molecules metabolic characteristic increases geometrically Enzyme 1 such as the concentration an enzyme cascade. of a second messenger x, Receptor or the membrane potential Vm, the regulatory outcome results from the integrated Enzyme input from both receptors.↑x] or Tv.↓ X)or V Ne△X]orVm R
Four features of signaltransducing systems