General introduction Ion channels G-protein coupled receptors Second messengers Tyrosine kinase receptors From plasma membrane to the nucleus Regulation of gene expression Cytokine signaling Cell cycle Apoptosis Cell signaling and diseases
General introduction Ion channels G-protein coupled receptors Second messengers Tyrosine kinase receptors From plasma membrane to the nucleus: Regulation of gene expression Cytokine signaling Cell cycle Apoptosis Cell signaling and diseases
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Eukaryotic cell cycle M Phase Mitosis(nuclear G2 Phase division) and Go Phase No dNa cytokinesis Terminally synthesis (cell division) differentiated RNA and yield two cells withdraw protein daughter cells. from cell cycle thesis indefinitely. continue M GO 1 h R oint 34h A cell returning from Go enters at early GI phas GI s 6-12h 6-8h GI Phase RNA and protein synt No dna synthesis S Phase DNA synthesis Restriction point doubles the A cell that passes this amount of dNA point is committed in the cell RNA to pass into S phase and protein also synthesized
Eukaryotic cell cycle
The cell cycle of the fission yeast S pombe Chromosome Spindle pole body duplication Spindle formation Chromosome segregation DNA Nuclear replication di ○;O Cytokinesis START Growth
The cell cycle of the fission yeast S. pombe
In vitro maturation of Xenopus oocytes and assay of maturation-promoting factor(MPF) Progesterone Sperm Arrested Meiosis I Meiotic Egg arrested Fertilized First oocyte (metaphase) interphase in meiosis ll egg cleavage (metaphase) b Assay for M Transfer MPF cytoplasm Eag arrested G2-arrested n metaphase ll yte
In vitro maturation of Xenopus oocytes and assay of maturation-promoting factor(MPF) G2-arrested oocyte