Effects on cardiovascular system First,it causes dilation of the large veins, resulting in pooling of blood in the veins.This diminishes preload (venous return to the heart),and reduces the work of the heart. Second,nitroglycerin dilates the coronary vasculature,providing increased blood supply to the heart muscle.Nitroglycerin causes a decrease in myocardial oxygen consumption because of decreased cardiac work
Effects on cardiovascular system ◼ First, it causes dilation of the large veins, resulting in pooling of blood in the veins. This diminishes preload (venous return to the heart), and reduces the work of the heart. ◼ Second, nitroglycerin dilates the coronary vasculature, providing increased blood supply to the heart muscle. Nitroglycerin causes a decrease in myocardial oxygen consumption because of decreased cardiac work
Pharmacokinetics The time to onset of action varies from one minute for nitroglycerin to more than one hour for isosorbide mononitrate. Significant first-pass metabolism of nitroglycerin occurs in the liver. either sublingually or via a transdermal
Pharmacokinetics ◼ The time to onset of action varies from one minute for nitroglycerin to more than one hour for isosorbide mononitrate. ◼ Significant first-pass metabolism of nitroglycerin occurs in the liver. ◼ either sublingually or via a transdermal