Plant-derived products Vinca alkaloids Etoposides Taxanes
6 Plant-derived products Vinca alkaloids Etoposides Taxanes
Hormonal agent Hormone antagonists Hormone agonists
7 Hormone antagonists Hormone agonists Hormonal agent
(2)According to biochemistry mechanisms of antitumor effect a.Agents affecting biosynthesis of nucleic acid b.Agents affecting structure and function of DNA c.Agents affecting transcription process and interrupting synthesis of RNA d.Agents interfering with the formation and function of proteins. e.Agents affecting hormone homeostasis
8 （2）According to biochemistry mechanisms of antitumor effect a. Agents affecting biosynthesis of nucleic acid b. Agents affecting structure and function of DNA c. Agents affecting transcription process and interrupting synthesis of RNA d. Agents interfering with the formation and function of proteins. e. Agents affecting hormone homeostasis
2.Mechanism of pharmacologic action (1)Cell biology mechanisms of antitumor effect (2)Biochemistry mechanisms of antitumor effect
9 2. Mechanism of pharmacologic action （1） Cell biology mechanisms of antitumor effect （2） Biochemistry mechanisms of antitumor effect
(1)Cell biology mechanism of antitumor effect a.Cell Cycle-Nonspecific (CCNS)Agents: Alkylating agent,Antibiotics, Platinum antitumor compound a.Cell Cycle-Specific (CCS)Agents: Methotrexate:S phase Vinca alkaloid:M phase
10 （1） Cell biology mechanism of antitumor effect a. Cell Cycle-Nonspecific (CCNS) Agents: Alkylating agent, Antibiotics, Platinum antitumor compound a. Cell Cycle-Specific (CCS) Agents: Methotrexate: S phase Vinca alkaloid: M phase