BIOCHEMISTRYANDMOLECULARBIOLOGY2.GeneticDiseases:Chromosome disordersThese diseases are caused by the loss, gain, or abnormalarrangementof one ormoreof the46chromosomescomposing the human diploid genomeDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY 2. Genetic Diseases: These diseases are caused by the loss, gain, or abnormal arrangement of one or more of the 46 chromosomes composing the human diploid genome Chromosome disorders
BIOCHEMISTRYANDMOLECULARBIOLOGY2.GeneticDiseases:Somatic cell gene defectsThese mutations are not inherited except by the cells inthe lineage of the mutated cell. Somatic cell genemutations are important in tumorigenesisDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY 2. Genetic Diseases: These mutations are not inherited except by the cells in the lineage of the mutated cell. Somatic cell gene mutations are important in tumorigenesis. Somatic cell gene defects
BIOCHEMISTRYANDMOLECULARBIOLOGY2.GeneticDiseases:MitochondrialmutationMitochondria contain circular molecules of DNA(mtDNA),eachofwhichcodesfor13of theapproximately 100 polypeptides required for the processof oxidative phosphorylation, as well as for 2 species ofrRNAs and 22 kinds of tRNA..mtDNAismaternallyinheritedbecausemitochondriafrom the sperm cell do not enter the fertilized eggDepartment of Biochemistryand Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY 2. Genetic Diseases: Mitochondria contain circular molecules of DNA (mtDNA), each of which codes for 13 of the approximately 100 polypeptides required for the process of oxidative phosphorylation, as well as for 2 species of rRNAs and 22 kinds of tRNA . mtDNA is maternally inherited because mitochondria from the sperm cell do not enter the fertilized egg. Mitochondrial mutation
ABIOCHEMISTRYANDMOLECULARBIOLOGY2. GeneticDiseases:MitochondrialmutationMitachandrianregion inanimationDmatrixintermembranecytoplasmspaceDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY 2. Genetic Diseases: Mitochondrial mutation
BIOCHEMISTRYANDMOLECULARBIOLOGYBeladi (right)her sonAdwards (left)is disableDepartment of Biochemistryand Molecular Biology,MedicineSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Beladi (right) , her son Adwards (left) is disable