上商充通大￥ What Is Metastasis? 1.Cancer cells Blood invade surrounding vessel tissues and vessels 2.Cancer cells are transported by the circulatory system to distant sites 3.Cancer cells reinvade and grow at new location
Shanghai Jiao Tong University
h 上商充通大￥ Shanghai Jiao Tong University Basic facts of cancer most common cause of death from disease (中 国第一位死因；死180万/年) morbidity getting higher gradually chemotherapy,some curative,mostly palliative almost all the anticancer drugs can be produced in China 国际抗癌联盟第21届世界抗癌大会，2010,8月18日-21 日，中国 2008,全球1270万人患癌，死760万
Shanghai Jiao Tong University Basic facts of cancer ü most common cause of death from disease （中 国第一位死因；死180万/年） ü morbidity getting higher gradually ü chemotherapy, some curative, mostly palliative ü almost all the anticancer drugs can be produced in China ü 国际抗癌联盟第21届世界抗癌大会，2010，8月18日-21 日，中国 ü 2008，全球1270万人患癌，死760万
上游充通大￥ 后 Shanghai Jiao Tong University One in seven people will be diagnosed with cancer during their lifetime. liver cancer lung cancer 2.6 million new cancer cases per year in China currently and the incidence is increasing rapidly due to longer life-span and change of life styles.一陈竺
Shanghai Jiao Tong University One in seven people will be diagnosed with cancer during their lifetime. liver cancer lung cancer 2.6 million new cancer cases per year in China currently and the incidence is increasing rapidly due to longer life-span and change of life styles. －陈竺
上浒文通大学 Causes of cancer Shanghai Jiao Tong University genetic predisposition:tumor suppressor genes deleted or damaged,etc. exposure to environmental carcinogens: radiation,chemicals (including ones in food), viruses(1/5癌症由慢性感染引起，如人类乳 头瘤病毒引起宫颈癌；乙肝病毒引起肝癌)，… In a healthy body immune system can recognize and destroy foreign cells.If .. √生活方式（吸烟；肥胖；）
Shanghai Jiao Tong University Causes of cancer ü genetic predisposition: tumor suppressor genes deleted or damaged, etc. ü exposure to environmental carcinogens: radiation, chemicals (including ones in food), viruses（1／5癌症由慢性感染引起，如人类乳 头瘤病毒引起宫颈癌；乙肝病毒引起肝癌 ）, … ü In a healthy body immune system can recognize and destroy foreign cells. If … ü 生活方式（吸烟；肥胖；…）
上游充通大￥ Shanghai Jiao Tong University radiotherapy chemotherapy free radicals replisome stalling alkylation environmental damage toxins replication UV light errors bulky adducts strand O-methyl breaks guanine pyrimidine dimers mismatches insertions/deletions
Shanghai Jiao Tong University