Choline Chotne Nat N SYNTHESIS OF ACETYLCHOLINE ·Tba8 bm8 olinium UPTAKE INTO 6 RECYCLING 3 STORAGE VESICLES OF CHOLINE Choline is taken up by neuron Ca 3 RELEASE OF NEUROTRANSMITTER ·月elease blocked by botulinum toxin DEGRADATION OF ACETYLCHOLINE BINDING TO esterase in the synaptic RECEPTOR cleft of neurotransmitter INTRACELLULAR RESPONSE 4.3 sis and release of acetylcholine from the cholinergic neuron
Neurotransmission at cholinergic neurons Involves six steps.Synthesis,storage, release,binding,degradation and recycling. 1)synthesis:choline+acetyl CoA=acetylcholine in the cytosol 2)storage:packaged into vesicles 3)release of acetylcholine:increase in the concentration of intracellular calcium promote the fusion and release of acetylcholine
Neurotransmission at cholinergic neurons ◼ Involves six steps. Synthesis, storage, release, binding, degradation and recycling. 1)synthesis: choline+acetyl CoA=acetylcholine in the cytosol 2)storage: packaged into vesicles 3) release of acetylcholine: increase in the concentration of intracellular calcium promote the fusion and release of acetylcholine