Drugs Affecting Reproductive System Ling Ding, Ph. D, Associate Professor College of Pharmaceutical Sciences Zhejiang University China 310058 Email:Id362@zju.edu.cn
Drugs Affecting Reproductive System Ling Ding, Ph. D., Associate Professor College of Pharmaceutical Sciences Zhejiang University China 310058 Email: ld362@zju.edu.cn
GnRH FSH Female antenor pitutary :242 and LH Pituitary Hormones ollicular phase Ovarian Cycle 下 progesterone systemIc effects PL⊥LLLL utenne Ovarian Hormones endometrium 1315 secretory phase
Female systemic effects
hypothalamus GnRH Male ante pituitary FSH testis seminiferous systemIc interstitial tubules y sperm effects produce produce sperm testosterone plus inhibin
Male systemic sperm effects
Sex hormones and related drugs Estrogens and antiestrogens Progestogens and antiprogestogens ● Contraceptive drugs Drugs acting on uterus smooth muscle
• Estrogens and antiestrogens • Contraceptive drugs • Drugs acting on uterus smooth muscle • Progestogens and antiprogestogens Sex hormones and related drugs
Estrogens and antiestrogens Three maior naturally occurring oestrogens in women Estradiol (e2) the predominant form in nonpregnant females Estrone(el)produced during menopause Estriol(e3) the primary oestrogen of pregnancy
Three major naturally occurring oestrogens in women • Estradiol (E2) the predominant form in nonpregnant females • Estrone (E1) produced during menopause • Estriol (E3) the primary oestrogen of pregnancy Estrogens and antiestrogens