Drugs for treatment of respiratory diseases Huifang Tang Department of pharmacology Zhe jiang University,school of medicine tanghuifang@zju.edu.cn Research building C422 2012-3-28
Huifang Tang Department of pharmacology Zhejiang University, school of medicine tanghuifang@zju.edu.cn Research building C422 2012-3-28
Antiasthmatic drugs Why asthma makes it hard to breathe Bronchial asthma Air enters the respiratory syste inflammation from the nose and mouth and travels through the bronchial tubes bronchoconstriction airway hyperresponsiveness In a non-asthmatic person In an asthmatic person, the the muscles around the muscles of the bronchial tube bronchial tubes are relaxed tighten and thicken, and the and the tissue thin air passages decor allowing for easy inflamed and mucus airflow filled, making it difficult for air to move Pathophysiology Asthma Asthmatic Lung Inflamed bronchial tube of an asthmatic Normal bronchial tube
Bronchial asthma： inflammation; bronchoconstriction; airway hyperresponsiveness
Antiasthmatic drugs Immunological and non-immunological stimuli Airway inflammation bronchoconstriction glucocorticosteroids P2 receptor agonists disodium cromoglycate theophylline leukotriene modifiers muscarinic antagonists Airway hyperresponsiveness Wheezing(asthmatic symptoms)
Antiasthmatic drugs Blood vessel Decreased Mucus Trarsport Airway Cationic Proteins pithelrum Epitiigliail Cell [EIge Recruitment EdemA Increased Increased Release Mucus of Tachykinins a:/ Sensory C F Ibers E Inflammatory cellsas E(Mast Cells, Eosinophils 甲■■口■■■■■■_■■_■口■ Smooth muscle Cysteiny l Leukotriene ■ ■■■■口 ■ Contraction and Proliferation Airway pathological changes in pathogenesis of bronchial asthma
Antiasthmatic drugs
Antiasthmatic drugs Plasma leak and edema Goblet cell discharge Antigens t Epithelial shedding T lymphocyte Neutrophil Sensory nerve Eosinophil Efferent nerve Macrophage Airway pathological changes in pathogenesis of bronchial asthma
Antiasthmatic drugs