Metabolic and signaling networks Zhenping Li, Rui-Sheng Wang, Xiang-Sun Zhang and Luonan Chen Detecting drug targets with minimum side effects in metabolic networks IET SyStems Biology, 3(6), 523-533, 2009 Chenping Li, Rui-Sheng Wang, Xiang-Sun Zhang Mass Flow Model and Essentiality of Enzymes in Metabolic Networks Lecture Notes in Operations Research, 9, pp. 182-190, World Publishing Co orporation lIang 2008. Jin G, Zhou X, Wang H, Zhao H, Cui K, Zhang Xs, Chen L, Hazen SL, Li K, Wong St The Knowledge-Integrated Network Biomarkers Discovery for Major Adverse Cardiac events I Proteome Res7(9):4013-4021,2008
Metabolic and signaling networks Zhenping Li, Rui-Sheng Wang, Xiang-Sun Zhang and Luonan Chen. Detecting drug targets with minimum side effects in metabolic networks. IET Systems Biology, 3(6), 523-533, 2009 Zhenping Li, Rui-Sheng Wang, Xiang-Sun Zhang. Mass Flow Model and Essentiality of Enzymes in Metabolic Networks. Lecture Notes in Operations Research, 9, pp. 182-190, World Publishing Corporation, Lijiang, 2008. Jin G, Zhou X, Wang H, Zhao H, Cui K, Zhang XS, Chen L, Hazen SL, Li K, Wong ST The Knowledge-Integrated Network Biomarkers Discovery for Major Adverse Cardiac Events. J Proteome Res 7(9): 4013-4021,2008 6
Book about biomolecular networks BIOMOLECULAR NETWORKS n时如wg ILEY Luonan Chen, Rui-Sheng Wang, Xiang-Sun Zhang Biomolecular Networks: Methods and Applications in Systems Biology ohn Wiley& Sons, Hoboken, New Jersey. July, 2009
Luonan Chen, Rui-Sheng Wang, Xiang-Sun Zhang. Biomolecular Networks: Methods and Applications in Systems Biology. John Wiley & Sons, Hoboken, New Jersey. July, 2009. Book about Biomolecular networks 7
Yeast functional linkage network DNA repair synthesis poL 9-REV DNA dam (signal transduction 14DUN∠14583 SCIENCE Vol 306(26)2004 us 324-14-MEC314-ASE Clusters for Meiotic energy metabolism Clusters for DNA damage 9-HAD Mitochondrial -RFA3"DouDe- strand Nucleotide excision repair Ribosome Ribosome dna damage module 可分成564个模块,由 950个显著的块间相互 作用相连接 Clusters for cellular transport mRNA splicing Chromatin modeling
可分成564 个模块，由 950 个显著的块间相互 作用相连接。 Yeast functional linkage network DNA damage module SCIENCE Vol 306(26) 2004
°复杂网络的动态性质研究 复杂网络的静态结构研究 >小世界( Small world),尺度无关( Scale free),聚 类特性( Clustering)的确切数学模型。 >社团结构( Community Structure) ●。·●●··●●·
复杂网络的动态性质研究 复杂网络的静态结构研究 ➢ 小世界(Small world) ，尺度无关（Scale free)，聚 类特性 (Clustering) 的确切数学模型。 ➢ 社团结构 (Community Structure) ➢ ………… 9
复杂网络的模块化性质 复杂网络中存在模块或者社区结构( Module or Community structure) 模块或者社区定义为网络中内部连接稠密,与外部连 接稀疏的节点的集合( Filippo Radicchi et. al. PNas, Vol.101,No.9,2658-2663,2004). 数学表述: ∑h(V)>∑ kout i∈V 其中v是子图,K是顶点的度。即孑子图v是模块的条件是模块内 顶点的内部连边的度值之和大于模块内顶点的外部连边的度值之 和。 PNAS-Proc. Natl. acad.Sci.USA美国科学院院刊
10 复杂网络的模块化性质 复杂网络中存在模块或者社区结构 (Module or Community structure) 模块或者社区定义为网络中内部连接稠密，与外部连 接稀疏的节点的集合 (Filippo Radicchi et. al. PNAS, Vol.101, No.9, 2658-2663, 2004). 数学表述: 其中V是子图，K是顶点的度。即子图V是模块的条件是模块内 顶点的内部连边的度值之和大于模块内顶点的外部连边的度值之 和。 PNAS ---- Proc. Natl. Acad. Sci. USA 美国科学院院刊