二、Treatment of herpesvirus infections Acyclovir Ganciclovir
二、Treatment of herpesvirus infections Acyclovir Ganciclovir
Acyclovir 【Antiviral actions and clinical uses】 1.Antiviral spectrum Acyclovir is effective against DNA virus herpesviruses:herpes simplex virus-1 (HSV-1), HSV-2,varicella-zoster virus and Epstein-Barr virus,but CMV is resistant 2.Acyclovir is the treatment of choice in herpes simplex encephalitis,genital herpes infections
Acyclovir 【Antiviral actions and clinical uses】 1. Antiviral spectrum Acyclovir is effective against DNA virus herpesviruses: herpes simplex virus-1 (HSV-1), HSV-2, varicella-zoster virus and Epstein-Barr virus, but CMV is resistant 2. Acyclovir is the treatment of choice in herpes simplex encephalitis, genital herpes infections
【Mechanism of action】 Acyclovir ↓thymidine kinase monophosphate derivative host's celluar enzymes Acyclovir triphosphate Inhibit viral DNA incorporate into polymerase the viral DNA inhibits viral DNA synthesis
【Mechanism of action】 Acyclovir monophosphate derivative Inhibit viral DNA polymerase inhibits viral DNA synthesis incorporate into the viral DNA thymidine kinase Acyclovir triphosphate host’s celluar enzymes