Cell Wall Synthesis Inhibits cell wall synthesis e Acyl Lipids Rifampin Inhibits RNA DNA Coiling, Transcription, and Translation Mycolic Acid RNA Polymerase NA Inhibit cell wal Arabinogalactan mRNA these asma (Ribosome Membrane PAS Cycloserine Inhibits synthesis (Protein of DNA precursors Inhibits cell wall synthesis Mycobacterium Fluoroquinolones tuberculosis Inhibit DNA Gyra bit prc nthesis (ATP) Inhibit pro SHH mmmm ATP Synthesis
0 20 40 60 80 100 120 一月 二月 三月 四月 亚洲区 欧洲区 北美区
Cell Wall Synthesis Acyl Lipids DNA Coiling, Transcription, and Translation sQ-109 Inhibits cell wall RNA synthesis Arabinogalactan ( eptidoglycan mRNA 时 Mycobacterium Inhibit protein tuberculosis synthesis Nitroimidazoles Oxazolidinone (E.g. PA-824 oPc67683) Inhibit protein synthesis Novel, complex mechanisms of Inhibit cell wall synthesis ATP) AND Inhibit cell respiration Mechanism of action uncertain ell wall Diarylquinoline ATP Synthesis (TMC 207) hibits ATP synthase
Isonizid Isonizid(异烟肼工NH) o Isoniazid is the most active drug for the treatment of tuberculosis caused by susceptible strains o Isoniazid penetrates into macrophages and is CONHNH2 active against both extracellular and Isoniazid intracellular organisms o In vitro, isoniazid inhibits most tubercle bacilli in a concentration of 0.025~0.05 ug/mL CH3 or less and is bactericidal for actively growing tubercle bacilli. it is less effective against OH HOH,C atypical mycobacterial species CH2OH Pyridoxine
Isonizid (异烟肼,INH) Isoniazid is the most active drug for the treatment of tuberculosis caused by susceptible strains. Isoniazid penetrates into macrophages and is active against both extracellular and intracellular organisms. In vitro, isoniazid inhibits most tubercle bacilli in a concentration of 0.025~0.05 μg/mL or less and is bactericidal for actively growing tubercle bacilli. It is less effective against atypical mycobacterial species. Isonizid
Cell Wall Synthesis Inhibits cell wall synthesis e Acyl Lipids Rifampin Inhibits RNA DNA Coiling, Transcription, and Translation Mycolic Acid, RNA Polymerase NA Inhibit cell wal Arabinogalactan (NA) mRNA these asma (Ribosome Membrane PAS Cycloserine Inhibits synthesis (Protein of DNA precursors Inhibits cell wall synthesis Mycobacterium Fluoroquinolones tuberculosis Inhibit DNA Gyra bit prc nthesis (ATP) Inhibit pro SHH mmmm ATP Synthesis
0 20 40 60 80 100 120 一月 二月 三月 四月 亚洲区 欧洲区 北美区
Isonizid Pharmacokinetics o Absorbtion: Isoniazid is readily absorbed from the gastrointestinal tract. A 300-mg oral dose(5 mg/kg in children )achieves peak plasma concentrations of 3-5 mca/mL within 1-2 hours o Distribution: Isoniazid diffuses readily into all body fluids and tissues o Metabolism: liver N-acetyltransferase(N乙酰转 移酶) rapid acetylators--hepatitis slow acetylators-- Peripheral neuropathy
Pharmacokinetics Absorbtion: Isoniazid is readily absorbed from the gastrointestinal tract. A 300-mg oral dose (5 mg/kg in children) achieves peak plasma concentrations of 3–5 mcg/mL within 1–2 hours. Distribution: Isoniazid diffuses readily into all body fluids and tissues. Metabolism: liver N-acetyltransferase(N乙酰转 移酶) ⚫ rapid acetylators -- hepatitis ⚫ slow acetylators-- Peripheral neuropathy Isonizid