Pharmacodynamicsl. Theanti-inflammatoryactivitymechanism: these drugs inhibit biosynthesis ofprostaglandins in peripheral nerves2.Antipyretic effectsmechanism: these drugs inhibit biosynthesis ofprostaglandins in CNS3.Analgesic effectsmechanism: these drugs inhibit biosynthesis ofprostaglandins in peripheral nerves
Pharmacodynamics 1. The anti-inflammatory activity mechanism: these drugs inhibit biosynthesis of prostaglandins in peripheral nerves. 2. Antipyretic effects mechanism: these drugs inhibit biosynthesis of prostaglandins in CNS. 3. Analgesic effects mechanism: these drugs inhibit biosynthesis of prostaglandins in peripheral nerves
SalicylatesASPIRIN and otherSalicylatesChemistryAspirin is a weak organic acid and is one of theoldest known drugs for the relief of fever and painAspirin itself is an acid with a pKa of 3.5 and isrelatively insoluble in water, while its sodium orcalcium salts have enhanced solubilityAspirin remains the standard to which mostNSAIDs are compared for efficacy
Salicylates ASPIRIN and other Salicylates Chemistry Aspirin is a weak organic acid and is one of the oldest known drugs for the relief of fever and pain. Aspirin itself is an acid with a pKa of 3.5 and is relatively insoluble in water, while its sodium or calcium salts have enhanced solubility. Aspirin remains the standard to which most NSAIDs are compared for efficacy
PharmacokineticsAspirin and related salicylates are rapidly absorbedThepeakplasmaupon oral administration.1 to 2 hoursconcentrationof aspirinoccursfollowingoral administrationmost absorption occurring in the small intestine.Factors of influencing absorptionThe pH of the stomachthe gastric emptying time of the stomachfood
Pharmacokinetics Aspirin and related salicylates are rapidly absorbed upon oral administration. The peak plasma concentration of aspirin occurs 1 to 2 hours following oral administration. most absorption occurring in the small intestine. Factors of influencing absorption The pH of the stomach the gastric emptying time of the stomach food
PreparationofaspirinEnteric-coated aspirin tablets have a variablerate of dissolution depending on the preparationbut are somewhat useful for prevention ofstomach ulceration and gastric distressAbsorption of aspirin from rectal suppositoriesis slower and more variable than from oraladministration
Preparation of aspirin Enteric-coated aspirin tablets have a variable rate of dissolution depending on the preparation but are somewhat useful for prevention of stomach ulceration and gastric distress. Absorption of aspirin from rectal suppositories is slower and more variable than from oral administration
Aspirin is immediately hydrolyzed by variousesterases in the stomach and in the liver toacetate and salicylic acid. Salicylic acid isglucuronidated, conjugated to glycine to formsalicyluric acid (the major metabolic pathway)oxidized to gentisic acid (a minor metabolicpathway), or remains free as salicylic acid,which is secreted in the proximal tubule of thekidney
Aspirin is immediately hydrolyzed by various esterases in the stomach and in the liver to acetate and salicylic acid. Salicylic acid is glucuronidated, conjugated to glycine to form salicyluric acid (the major metabolic pathway), oxidized to gentisic acid (a minor metabolic pathway), or remains free as salicylic acid, which is secreted in the proximal tubule of the kidney