Part a Pharmacokinetic processes u Characteristics of Passive Transport 口口口口口口 not involving specific carriers Energy-independent no saturability no competition with other drugs Concentration gradient(down-hill)
Characteristics of Passive Transport not involving specific carriers Energy-independent no saturability no competition with other drugs Concentration gradient (down-hill) Part A Pharmacokinetic Processes
Part a Pharmacokinetic processes 口(2) Active Transport o Characteristics of active transport o Involving specific carrier aEnergy-dependent 口 Saturability o Competition at same carrier o Moving against concentration gradient(up-hill)
(2) Active Transport Characteristics of active transport Involving specific carrier Energy-dependent Saturability Competition at same carrier Moving against concentration gradient (up-hill) Part A Pharmacokinetic Processes
Part a Pharmacokinetic processes 口(3) Others 口 Filtration through pores(膜孔滤过) 口 Facilitated diffusion(易化扩散) 口 Endocytosis(内吞) 囗 Pinocytosis(胞饮) 口Ion- pair transport(离子对转运)
(3) Others Filtration through pores（膜孔滤过） Facilitated diffusion（易化扩散） Endocytosis（内吞） Pinocytosis（胞饮） Ion-pair transport（离子对转运） Part A Pharmacokinetic Processes
Transporter Receptor Channel Three types offunctional membrane proteinS
Three types of functional membrane proteins
ATP choroid plexus (BCSFB) B rain aln brain capillary (BBB) hepatocyte OAT OAT proximal tubular cell Transporters OCTOCT 之 ept of drugs in PK ATr' 数式 processes Mrn tp MI ver kidney ATP Per Pgp intestine
Transporters of drugs in PK processes