Examination paper of (pharmacology)for the the second term of 2005-2006 academic year of Chongqing medical university Mode of the examination:closed,Time for the examination:90 minutes The grade and the subject which the examination paper be applied grade 2006, medical science Guides of the examination Students of chongqing medical university attend any examonation that organizied by the university must obey "The role of the examination room of chongqingmedical university"rigoroursly.The the students who violate the discipline and cheating in the examination will be punished rigorously by university according to the related rule. Any supervisior of the examinations must carry out "The rule of the task and responsibility in the examinations"rigoroursly."The additional rule of the further specification of the task in the examinations "and ensure the order of the examination room by carry out "The responsibility of the supervisior of chongqing medical university"seriously. Question number Total marks Score Sign by appraiser 1.Type A:(DIRECTIONS:Each question below contains five suggested answers. Choose the best one response to each question.The marks of each question is 1,totally 70 marks): 1.The pharmacokinetic value that most reliably reflects the amount of drug absorbed from the sites in which drug is given is 【 】 A.the peak blood concentration B.the time that is needed for drug to arrive at peak blood concentration after administration C.volume of distribution D.the first-order rate constant
1 Examination paper of《pharmacology》for the the second term of 2005—2006 academic year of Chongqing medical university Mode of the examination：closed， Time for the examination：90 minutes The grade and the subject which the examination paper be applied ： grade 2006， medical science. Guides of the examination Students of chongqing medical university attend any examonation that organizied by the university must obey “The role of the examination room of chongqingmedical university”rigoroursly. The the students who violate the discipline and cheating in the examination will be punished rigorously by university according to the related rule. Any supervisior of the examinations must carry out “The rule of the task and responsibility in the examinations ”rigoroursly,“The additional rule of the further specification of the task in the examinations ”and ensure the order of the examination room by carry out“The responsibility of the supervisior of chongqing medical university”seriously. Question number Ⅰ Ⅱ Ⅲ Ⅳ Total marks Score Sign by appraiser I.Type A：（DIRECTIONS: Each question below contains five suggested answers. Choose the best one response to each question. The marks of each question is 1，totally 70 marks）: 1. The pharmacokinetic value that most reliably reflects the amount of drug absorbed from the sites in which drug is given is 【 】 A. the peak blood concentration B. the time that is needed for drug to arrive at peak blood concentration after administration C. volume of distribution D. the first-order rate constant College or department class and grade name student number
E.the area under the blood concentration-time curve 2.After given orally.which of following drugs is the most easily absorbed from the bowels (suppose the value of pH in the bowel is 6.0)? 】 A.acetaminophen,weak acid,pKa 9.5 B.aspirin,weak acid,pKa 3.5 C.phenobarbital.weak acid.pKa 8.1 D.atropine.weak base.pKa 9.7 E.clonidine.weak base,pKa 8.3 3.If a drug has an elimination half time (t)of 24 hours and 10 mg is administered intravenously once daily.how many days are needed at least for the drug to arrive at Css? 【 】 A.1 day B.3 days C.5 days D.7 days E.9 days 4.The characteristics of simple diffusion of drugs include the fol lowing items EXCEPT【 】 A.No energy is neededB.No carrier is needed C.Transportation is concentration-dependence existing on two sides of the transport regions D.It is also called down hill E.The pH value of transportation surroundings has no influence on it 5.The onset and duration of action of barbiturates are mainly a function of its【 】 A.lipid solubility B.molecular weight C.plasma protein binding D.renal excretion E.method of administration 6.The drug of choice for the treatment of anaphylactic shock is 】 A.histamine B.adrenaline C.noradrenaline D.isoproterenol E.diphenhydramine 2
2 E. the area under the blood concentration-time curve 2. After given orally, which of following drugs is the most easily absorbed from the bowels (suppose the value of pH in the bowel is 6.0)? 【 】 A. acetaminophen, weak acid, pKa 9.5 B.aspirin, weak acid, pKa 3.5 C.phenobarbital, weak acid, pKa 8.1 D.atropine, weak base, pKa 9.7 E.clonidine, weak base, pKa 8.3 3. If a drug has an elimination half time (t1/2) of 24 hours and 10 mg is administered intravenously once daily, how many days are needed at least for the drug to arrive at Css? 【 】 A.1 day B.3 days C.5 days D.7 days E.9 days 4. The characteristics of simple diffusion of drugs include the following items EXCEPT 【 】 A. No energy is neededB. No carrier is needed C.Transportation is concentration-dependence existing on two sides of the transport regions D.It is also called down hill E.The pH value of transportation surroundings has no influence on it 5. The onset and duration of action of barbiturates are mainly a function of its 【 】 A.lipid solubility B.molecular weight C.plasma protein binding D.renal excretion E.method of administration 6. The drug of choice for the treatment of anaphylactic shock is 【 】 A.histamine B.adrenaline C.noradrenaline D.isoproterenol E.diphenhydramine
7.Functionally.a patient with myasthenia gravis resembles a person who has been treated with low doses of 】 A.atropine B.tubocurarine C.methachol ine D.muscarine E.propranolol 8.Which of following mechanisms is responsible for el imination of endogenous acetylcholine? 【 】 A.the enzyme called choline acetyltransferase B.the enzyme called acetylcholinesterae C.the uptake by peripheral tissues D.the uptake by nerve endings E.the excretion by kidneys 9.A predictably dangerous side effect of propranolol is[ 】 A.inducting hypertension B.inducting cardiac arrhythmia C.inducting asthmatic attacks D.inducting elevation of sugar level in blood E.inducting retention of sodium and water in body 10.Which of fol lowing drugs is suitable for patients with hypertensive crisis? A.clonidine B.prazosin C.sodium nitroprusside D.nifedipine E.hydrochlorothiazide 11.Ba-adrenergic receptor is involved in which of the following adrenergic responses【 】 A.stimulatiing myocardial contractility B.relaxing bronchial smooth muscle C.increasing heart rate D.contracting gastrointestinal smooth muscle E.improving microcirculation 12.The characteristics of hepatic drug enzymes include the fol lowing items EXCEPT【 】 A.The enzumes have high specificity B.Large individual difference of the enzymes exist 3
3 7. Functionally, a patient with myasthenia gravis resembles a person who has been treated with low doses of 【 】 A.atropine B.tubocurarine C.methacholine D.muscarine E.propranolol 8. Which of following mechanisms is responsible for elimination of endogenous acetylcholine? 【 】 A.the enzyme called choline acetyltransferase B.the enzyme called acetylcholinesterae C.the uptake by peripheral tissues D.the uptake by nerve endings E.the excretion by kidneys 9. A predictably dangerous side effect of propranolol is 【 】 A.inducting hypertension B.inducting cardiac arrhythmia C.inducting asthmatic attacks D.inducting elevation of sugar level in blood E.inducting retention of sodium and water in body 10. Which of following drugs is suitable for patients with hypertensive crisis? 【 】 A. clonidine B.prazosin C.sodium nitroprusside D.nifedipine E.hydrochlorothiazide 11. 2-adrenergic receptor is involved in which of the following adrenergic responses 【 】 A.stimulatiing myocardial contractility B. relaxing bronchial smooth muscle C.increasing heart rate D.contracting gastrointestinal smooth muscle E.improving microcirculation 12. The characteristics of hepatic drug enzymes include the following items EXCEPT 【 】 A.The enzumes have high specificity B.Large individual difference of the enzymes exist
C.The activities of enzumes is variable D.The activities of enzymes can be induced or inhibited by some drugs E.The enzymes catalyze the oxidation and reduction of drugs 13.Which of the fol lowing drugs is an antagonist of angiotension II receptor A.captopril B.phentolamine C.losartan D.hydralazine E.minoxidil 14.Which of following drugs can induce the attack of angina pectoris 【 】 A.clonidine B.propranolol C.hydrochlorothiazide D.candisartan E.hydralazine 15.Which of following drugs is selectively adrenergic Ba receptor agonist? 【 】 A.terbutaline B.ephedrine C.isoprenaline D.dopamine E.aminophylline 16.The preferred treatment of status epilepticus is intravenous administration of which of the following drugs? A.chlorpromazine B.diazepam C.succinylchol ine D.ethosuximide E.phenytoin 17.Vasodi lation can be caused by fol lowing drugs EXCEPT A.verapamil B.phentolamine C.prasozin D.propranolol E.aminophylline 18.Which of following drugs is suitable to treat the shock patients with insufficiencies of renal and cardiac function? 【 】 A.terbutaline B.ephedrine C.ipratropinum D.atropine E.dopamine 19.Which of following drugs is very suitable to treat hypertensive patients with anxiety and alimentary ulcers 【 】 A.hydralazine B.clonidine C.propranolol D.nifedipine E.captopril 20.Following drugs may overturn the elevation of blood pressure caused by adrenaline when they are used in combination of adrenaline EXCEPT 【 A.phentolamine B.prazosin C.chlorpromazine D.atropine E.imipramine 21.The good candidate for treatment of depression is 】 4
4 C.The activities of enzumes is variable D.The activities of enzymes can be induced or inhibited by some drugs E.The enzymes catalyze the oxidation and reduction of drugs 13. Which of the following drugs is an antagonist of angiotension II receptor 【 】 A.captopril B.phentolamine C.losartan D.hydralazine E.minoxidil 14. Which of following drugs can induce the attack of angina pectoris 【 】 A.clonidine B.propranolol C.hydrochlorothiazide D.candisartan E.hydralazine 15. Which of following drugs is selectively adrenergic 2 receptor agonist? 【 】 A.terbutaline B.ephedrine C.isoprenaline D.dopamine E.aminophylline 16. The preferred treatment of status epilepticus is intravenous administration of which of the following drugs? 【 】 A. chlorpromazine B.diazepam C.succinylcholine D.ethosuximide E.phenytoin 17. Vasodilation can be caused by following drugs EXCEPT 【 】 A.verapamil B.phentolamine C.prasozin D.propranolol E.aminophylline 18. Which of following drugs is suitable to treat the shock patients with insufficiencies of renal and cardiac function? 【 】 A.terbutaline B.ephedrine C.ipratropinum D.atropine E. dopamine 19. Which of following drugs is very suitable to treat hypertensive patients with anxiety and alimentary ulcers 【 】 A.hydralazine B.clonidine C.propranolol D.nifedipine E.captopril 20. Following drugs may overturn the elevation of blood pressure caused by adrenaline when they are used in combination of adrenaline EXCEPT 【 】 A.phentolamine B.prazosin C.chlorpromazine D.atropine E.imipramine 21.The good candidate for treatment of depression is 【 】
A.lithium carbonate B.clozapine C.norepinephrine D.atropine E.fluoxetine 22.Chlorpromazine can be used to treat nausea and vomiting caused by many factors EXCEPT for【 】 A.digoxin B.radiation C.pregnancy D.motion sickness E.morphine 23.The good candidate for treatment of asphyxia of newborn baby is 【 】 A.Nikethamide B.caffeine C.lobeline D.Amphetamine E.piracetam 24.The use of morphine is contraindicated in A.myocardial infarction B.acute pulmonary edema C.simple diarrhea D.kidney colic E.bronchial asthma 25.The major pharmacological mechanism of naloxone is A.exciting the u receptor B.antagonizing the u receptor C.exciting the a receptor D.exciting the B receptor E.blockage of M receptor 26.Which drug below dose not belong to narcotic analgesics[ 】 A.codein B.pentazocine C.methadone D.meperidine E.morphine 27.Which drug has severe side effects in gastrointestinal tract 】 A.indomethacin B.acetaminophen C.naproxen D.celecoxib E.rofecoxib 28.The effects of aspirin do not include 】 A.reduction of fever B.pain relief C.decrease the PGs synthesis in inflamed tissues D.reduction of bleeding tendency E.impaired of protective mucus synthesis 29.True statements about codeine include that it 】 A.produces naloxone-reversible respiratory depression B.may cause hypotension as a result of histamine release C.has antitussive properties D.is partially biotransformed to morphine E.all description above are correct 30.Which drug below has high incidence rate of rhabdomyolysis 】 A.clofibrate B.nicotinic acid C.colestipol D.lovastatin E.Vit E 31.Which drug below can acts on PPAR alfa 】 A.clofibrate B.nicotinic acid C.colestipol D.lovastatin E.piracetam 5
5 A.lithium carbonate B.clozapine C.norepinephrine D.atropine E.fluoxetine 22.Chlorpromazine can be used to treat nausea and vomiting caused by many factors EXCEPT for 【 】 A.digoxin B.radiation C.pregnancy D.motion sickness E.morphine 23.The good candidate for treatment of asphyxia of newborn baby is 【 】 A.Nikethamide B.caffeine C.lobeline D.Amphetamine E.piracetam 24．The use of morphine is contraindicated in【 】 A.myocardial infarction B.acute pulmonary edema C.simple diarrhea D.kidney colic E.bronchial asthma 25.The major pharmacological mechanism of naloxone is【 】 A.exciting the μreceptor B.antagonizing theμreceptor C.exciting theαreceptor D.exciting theβreceptor E.blockage of M receptor 26.Which drug below dose not belong to narcotic analgesics【 】 A.codein B.pentazocine C.methadone D.meperidine E.morphine 27.Which drug has severe side effects in gastrointestinal tract 【 】 A.indomethacin B.acetaminophen C.naproxen D.celecoxib E.rofecoxib 28.The effects of aspirin do not include 【 】 A.reduction of fever B.pain relief C.decrease the PGs synthesis in inflamed tissues D.reduction of bleeding tendency E.impaired of protective mucus synthesis 29.True statements about codeine include that it 【 】 A.produces naloxone-reversible respiratory depression B.may cause hypotension as a result of histamine release C.has antitussive properties D.is partially biotransformed to morphine E.all description above are correct 30.Which drug below has high incidence rate of rhabdomyolysis 【 】 A.clofibrate B.nicotinic acid C.colestipol D.lovastatin E.Vit E 31.Which drug below can acts on PPAR alfa 【 】 A.clofibrate B.nicotinic acid C.colestipol D.lovastatin E.piracetam