Examination paper of (pharmacology)for the the second term of 2005-2006 academic year of Chongqing medical university Mode of the examination:closed,Time for the examination:90 minutes The grade and the subject which the examination paper be applied grade 2006. medical science Guides of the examination Students of chongqing medical university attend any examonation that organizied by the university must obey "The role of the examination room of chongqingmedical university"rigoroursly.The the students who violate the discipline and cheating in the examination will be punished rigorously by university according to the related rule. Any supervisior of the examinations must carry out "The rule of the task and responsibility in the examinations "rigoroursly."The additional rule of the further specification of the task in the examinations and ensure the order of the examination room by carry out "The responsibility of the supervisior of chongqing medical university"seriously. Question number Ill IV Total marks Score Sign by appraiser I.Type A:(DIRECTIONS:Each question below contains five suggested answers. Choose the best one response to each question.The marks of each question is 1,totally 70 marks): 1.Drugs may be released slowly from various drug reservoirs after absorbed and stored in the body.The body reservoir that holds the largest amount of the barbiturate thiopental is【A】 A.fat B.lung C.liver D.muscle E.serum albumin 2.The most common route of excretion for drugs is B
1 Examination paper of《pharmacology》for the the second term of 2005—2006 academic year of Chongqing medical university Mode of the examination：closed， Time for the examination：90 minutes The grade and the subject which the examination paper be applied ： grade 2006， medical science. Guides of the examination Students of chongqing medical university attend any examonation that organizied by the university must obey “The role of the examination room of chongqingmedical university”rigoroursly. The the students who violate the discipline and cheating in the examination will be punished rigorously by university according to the related rule. Any supervisior of the examinations must carry out “The rule of the task and responsibility in the examinations ”rigoroursly,“The additional rule of the further specification of the task in the examinations ”and ensure the order of the examination room by carry out “ The responsibility of the supervisior of chongqing medical university”seriously. Question number Ⅰ Ⅱ Ⅲ Ⅳ Total marks Score Sign by appraiser I.Type A：（DIRECTIONS: Each question below contains five suggested answers. Choose the best one response to each question. The marks of each question is 1，totally 70 marks）: 1．Drugs may be released slowly from various drug reservoirs after absorbed and stored in the body. The body reservoir that holds the largest amount of the barbiturate thiopental is 【 A 】 A．fat B．lung C．liver D．muscle E．serum albumin 2．The most common route of excretion for drugs is 【 B 】 College or department class and grade name student number
A.Biliary tract B.Kidneys C.Lungs D.Feces E.Milk 3.If a drug has an elimination half time (tin)of 24 hours and 10 mg is administered intravenously once daily.how many days are needed at least for the drug to arrive at Css？【 C】 A.1 day B.3 days C.5 days D.7 days E.9 days 4.The pharmacokinetic value that most reliably reflects the amount of drug absorbed from the sites in which drug is given is E 】 A.the peak blood concentration B.the time that is needed for drug to arrive at peak blood concentration after administration C.volume of distribution D.the first-order rate constant E.the area under the blood concentration-time curve 5.After given orally.which of fol lowing drugs is the most easily absorbed from the bowels(suppose the value of pH in the bowel is 6.0)?A 】 A.acetaminophen,weak acid.pKa 9.5 B.aspirin,weak acid,pKa 3.5 C.phenobarbital,weak acid.pKa 8.1 D.atropine.weak base,pKa 9.7 E.clonidine.weak base.pKa 8.3 6.The characteristics of hepatic drug enzymes include the fol lowing items EXCEPT【A 】 A.The enzumes have high specificity B.Large individual difference of the enzymes exist C.The activities of enzumes is variable D.The activities of enzymes can be induced or inhibited by some drugs E.The enzymes catalyze the oxidation and reduction of drugs 7.Which of the following parameters is used to evaluate the safety of drugs 【C 】 A.EDso B.LDao C.TI D.efficacy E.potency 8.Gingival hyperplasia is a complication of long-term antiepileptic treatment with【D 】 2
2 A．Biliary tract B．Kidneys C．Lungs D．Feces E．Milk 3．If a drug has an elimination half time (t1/2) of 24 hours and 10 mg is administered intravenously once daily, how many days are needed at least for the drug to arrive at Css? 【 C 】 A．1 day B．3 days C． 5 days D．7 days E．9 days 4．The pharmacokinetic value that most reliably reflects the amount of drug absorbed from the sites in which drug is given is 【 E 】 A．the peak blood concentration B．the time that is needed for drug to arrive at peak blood concentration after administration C．volume of distribution D．the first-order rate constant E．the area under the blood concentration-time curve 5．After given orally, which of following drugs is the most easily absorbed from the bowels (suppose the value of pH in the bowel is 6.0)? 【 A 】 A．acetaminophen, weak acid, pKa 9.5 B．aspirin, weak acid, pKa 3.5 C．phenobarbital, weak acid, pKa 8.1 D．atropine, weak base, pKa 9.7 E．clonidine, weak base, pKa 8.3 6．The characteristics of hepatic drug enzymes include the following items EXCEPT 【 A 】 A．The enzumes have high specificity B．Large individual difference of the enzymes exist C．The activities of enzumes is variable D．The activities of enzymes can be induced or inhibited by some drugs E．The enzymes catalyze the oxidation and reduction of drugs 7．Which of the following parameters is used to evaluate the safety of drugs 【 C 】 A．ED50 B．LD50 C．TI D．efficacy E．potency 8．Gingival hyperplasia is a complication of long-term antiepileptic treatment with 【 D 】
A.phenobarbital B.primidone C.diazepam D.phenytoin E.valproic acid 9.Absence (petit mal)seizure is best treated with which of the fol lowing drugs? 【 E】 A.chlorpromazine B.phenytoin C.verapamil D.cabamazipine E.ethosuximide 10.The preferred treatment of status epilepticus is intravenous administration of which of the fol lowing drugs? B】 A.chlorpromazine B.diazepam C.succinylcholine D.ethosuximide E.phenytoin 11.The drug of choice for the treatment of anaphylactic shock is B】 A.histamine B.epinephrine (adrenaline)C.norepinephr ine(noradrenaline) D.isoproterenol (isoprenaline)E.diphenhydramine 12.Functionally.a patient with myasthenia gravis resembles a person who is being treated with low doses of【E】 A.atropine B.propranolol C.methacholine D.muscar ine E.tubocurarine 13.All the drugs belong to the catecholamine EXCEPT D 】 A.adrenaline B.dopamine C.noradrenaline D.ephedrine E.isoprenaline 14.All the following structures respond to B-adrenergic receptor stimulation EXCEPT【B 】 A.the ciliary muscle of the iris B.the radial muscle of the iris C.bronchial muscle D.the atrio ventrlcular node E.the sinoatrial node 15.The adrenal medulla secretes epinephrine in response to administration of 【E 】 A.atropine B.tubecurarine C.succinylchol ine D.methyldopa E.nicotine 16.Which of fol lowing mechanisms is responsible for elimination of endogenous noradrenaline?【D A.the enzyme called COM B.the enzyme called MAO C.the uptake by peripheral tissues D.the uptake by nerve endings
3 A．phenobarbital B．primidone C．diazepam D．phenytoin E．valproic acid 9．Absence (petit mal) seizure is best treated with which of the following drugs? 【 E 】 A．chlorpromazine B．phenytoin C．verapamil D．cabamazipine E．ethosuximide 10．The preferred treatment of status epilepticus is intravenous administration of which of the following drugs? 【 B 】 A．chlorpromazine B．diazepam C．succinylcholine D．ethosuximide E．phenytoin 11 ． The drug of choice for the treatment of anaphylactic shock is 【 B 】 A．histamine B．epinephrine (adrenaline) C．norepinephrine (noradrenaline) D．isoproterenol (isoprenaline) E．diphenhydramine 12．Functionally, a patient with myasthenia gravis resembles a person who is being treated with low doses of 【 E 】 A．atropine B．propranolol C．methacholine D．muscarine E．tubocurarine 13．All the drugs belong to the catecholamine EXCEPT 【 D 】 A．adrenaline B．dopamine C．noradrenaline D．ephedrine E．isoprenaline 14．All the following structures respond to -adrenergic receptor stimulation EXCEPT 【 B 】 A．the ciliary muscle of the iris B．the radial muscle of the iris C．bronchial muscle D．the atrio ventrlcular node E．the sinoatrial node 15．The adrenal medulla secretes epinephrine in response to administration of 【 E 】 A．atropine B．tubecurarine C．succinylcholine D．methyldopa E．nicotine 16．Which of following mechanisms is responsible for elimination of endogenous noradrenaline? 【 D 】 A．the enzyme called COM B．the enzyme called MAO C．the uptake by peripheral tissues D．the uptake by nerve endings
E.the excretion by kidneys 17.Which of following drugs is a pure acetylcholinesterase inhibitor? 【 A 】 A.physostigmine B.pilocarpine C.neostigmine D.muscarine E.acetylcholine 18.A predictably dangerous side effect of propranolol,is C A.inducting hypertensio B.inducting cardiac arrhythmia C.inducting asthmatic attacks D.inducting elevation of sugar level in blood E.inducting retention of sodium and water in body 19.Which of fol lowing symptoms still exists after large doses of atropine are used to treat the patients with organic phosphate intoxication? 【D A.excessive secretion salivation B.gastrointenstinal spasm C.bronchospam D.switching skeletal muscles E.miosis 20.Which of following drugs is suitable for patients with hypertensive crisis? 】 A.clonidine B.prazosin C.sodiumnitroprussid D.nifedipine E.hydrochlorothiazide 21.An important action of imipramine is the inhibition of B A.norepinephrine release B.norepinephr ine uptake C.acetylcholine release D.dopamine uptake E.serotonin synthesis 22.Which drug below dose not belong to narcotic analgesics B 】 A.codein B.pentazocine C.methadone D.meperidine E.morphine 23.The good candidate for treatment of mania is A 】 A.lithium carbonate B.clozapine C.norepinephrine D.atropine E.fluoxetine 24.Morphine dose not have【C】 A.sedation B.cough suppression C.inhibition of vomiting D.stimulation of intestinal smooth muscle E.respiratory suppression 25.The analgesic mechanism of meperidine is A】 4
4 E．the excretion by kidneys 17 ． Which of following drugs is a pure acetylcholinesterase inhibitor? 【 A 】 A．physostigmine B．pilocarpine C．neostigmine D．muscarine E．acetylcholine 18．A predictably dangerous side effect of propranolol, is 【 C 】 A．inducting hypertensio B．inducting cardiac arrhythmia C．inducting asthmatic attacks D．inducting elevation of sugar level in blood E．inducting retention of sodium and water in body 19．Which of following symptoms still exists after large doses of atropine are used to treat the patients with organic phosphate intoxication? 【 D 】 A．excessive secretion salivation B．gastrointenstinal spasm C．bronchospam D．switching skeletal muscles E．miosis 20．Which of following drugs is suitable for patients with hypertensive crisis? 【 C 】 A．clonidine B．prazosin C．sodiumnitroprussid D．nifedipine E．hydrochlorothiazide 21．An important action of imipramine is the inhibition of【 B 】 A．norepinephrine release B．norepinephrine uptake C．acetylcholine release D．dopamine uptake E．serotonin synthesis 22．Which drug below dose not belong to narcotic analgesics【 B 】 A．codein B．pentazocine C．methadone D．meperidine E．morphine 23．The good candidate for treatment of mania is 【 A 】 A．lithium carbonate B．clozapine C．norepinephrine D． atropine E．fluoxetine 24．Morphine dose not have【 C 】 A．sedation B．cough suppression C．inhibition of vomiting D．stimulation of intestinal smooth muscle E．respiratory suppression 25．The analgesic mechanism of meperidine is【 A 】
A.exciting the Hreceptor B.antagonizing the u receptor C.exciting the a receptor D.exciting the B receptor E.blockage of M receptor 26.The good candidate for treatment of morphine overdose toxicity is 【E 】 A.methadone B.meperidine C.propranolol D.codein E.naloxone 27.The drug which lacks anti-inflammatory action is B 】 A.aspirin B.acetaminophen C.naproxen D.celecoxib E.indomethacin 28.Which drug is high selective inhibitor of COX2[D 】 A.aspirin B.acetaminophen C.naproxen D.celecoxib E.indomethacin 29.Which substance involves in the mechanism of platelet aggregation inhibition of aspirin D】 A.PGE2 B.PGF2.C.PGI2 D.TXA2 E.substance P 30.The good candidate for treatment of respiratory failure caused by carbon monoxide is【 】 A.Nikethamide B.caffeine C.lobeline D.Amphetamine E.piracetam 31.Which drug below can inhibit cholesterol synthesis by HMG-CoA reductase inhibition【 D】 A.clofibrate B.nicotinic acid C.colestipol D.lovastatin E.piracetam 32.Which drug below is not useful for treatment of congestive heart failure C】 A.cardiac glycosides B.ACEI C.muscarinic agonist D.B,R antagonist E.PDE III inhibitor 33.Which drug below can agitate the toxicity caused by digoxin B A.potassium supply B.calcium supply C.antidigoxin antibody D.atropine E.phenytoin 34.A major pharmacological mechanisms of Amrinone is inhibition of 【E 】 A.HMG-CoA reductase B.ACE C.muscarinic R D.B,R E.PDE III 35.Amajor pharmacological mechanisms of cardiac glycosides is[E A.enhancement of cardiac ribosome function in protein synthesis 5
5 A．exciting the μreceptor B．antagonizing theμreceptor C．exciting theαreceptor D．exciting theβreceptor E．blockage of M receptor 26 ． The good candidate for treatment of morphine overdose toxicity is 【 E 】 A．methadone B．meperidine C．propranolol D．codein E．naloxone 27．The drug which lacks anti-inflammatory action is 【 B 】 A．aspirin B．acetaminophen C．naproxen D．celecoxib E．indomethacin 28．Which drug is high selective inhibitor of COX2【 D 】 A．aspirin B．acetaminophen C．naproxen D．celecoxib E．indomethacin 29 ． Which substance involves in the mechanism of platelet aggregation inhibition of aspirin 【 D 】 A．PGE2 B．PGF2α C．PGI2 D．TXA2 E．substance P 30．The good candidate for treatment of respiratory failure caused by carbon monoxide is 【 C 】 A．Nikethamide B．caffeine C．lobeline D．Amphetamine E．piracetam 31．Which drug below can inhibit cholesterol synthesis by HMG-CoA reductase inhibition 【 D 】 A．clofibrate B．nicotinic acid C．colestipol D．lovastatin E．piracetam 32．Which drug below is not useful for treatment of congestive heart failure 【 C 】 A．cardiac glycosides B．ACEI C．muscarinic agonist D．β1 R antagonist E．PDE III inhibitor 33．Which drug below can agitate the toxicity caused by digoxin 【 B 】 A ． potassium supply B ． calcium supply C ． antidigoxin antibody D． atropine E．phenytoin 34 ． A major pharmacological mechanisms of Amrinone is inhibition of 【 E 】 A．HMG-CoA reductase B．ACE C．muscarinic R D．β1 R E．PDE III 35．A major pharmacological mechanisms of cardiac glycosides is【 E 】 A．enhancement of cardiac ribosome function in protein synthesis