Pharmacokinetics·SD is a lower protein-binding drug andmay diffuse into the cerebrospinal fluidverymuch.Sulfonamidesandtheirmetabolitesareexcreted in the urine.Some of them havealower urinary solubility,especiallyat acidpH.Theymayprecipitateinurineproducingcrystalluria
Pharmacokinetics • SD is a lower protein-binding drug and may diffuse into the cerebrospinal fluid very much. • Sulfonamides and their metabolites are excreted in the urine. Some of them have a lower urinary solubility, especially at acid pH. They may precipitate in urine producing crystalluria
Clinical uses and drug selection.General infections-Urinary tract infections-Respiratory tract infections: bronchitis ;pneumonia-Epidemiccerebrospinal meningitis(ECM)-Soft tissue infections: otitis media ;sinusitis selection of drugs: SIZ ; SMZ ; SDForthe epidemic cerebrospinal meningitis,SDis the first choice
Clinical uses and drug selection • General infections - Urinary tract infections - Respiratory tract infections: bronchitis ; pneumonia - Epidemic cerebrospinal meningitis (ECM) - Soft tissue infections: otitis media ; sinusitis • selection of drugs: SIZ ; SMZ ; SD For the epidemic cerebrospinal meningitis , SD is the first choice