3 Antiasthmatic drugs Why asthma makes it hard to breathe Air enters the respiratory system from the nose and mouth and travels through the bronchial tubes In a non-asthmatic person, In an asthmatic person, the the muscles around th muscles of the bronchial tubes bronchial tubes are relaxed tighten and thicken, and the and the tissue thin air passages become allowing for easy inflamed and mucus. airflow difficult for air to move Inflamed bronchial tube of an asthmatic Normal bronchial tube
3. Antiasthmatic drugs
3 Antiasthmatic drugs Alertor macrophage dendritic ce 新 Mast cell 8少 Mucus plug Epthelial shedding nm mmm nn m ghm Nerve h n m n o activation oOOO Subepithelial fibrosis s Fibroblast Sensory nerve MurIS activation hypersecretion Plasma leakage Hyperplasia Edema cholinergic angiogenesis Bronchoconstriction Airway Hypertrophy/hyperplasia smooth musce Subcutaneous layer
3. Antiasthmatic drugs
Antiasthmatic drugs 口 Bronchodilators β Receptor agonists o Non-selective adrenaline, isoprenaline β2- selective: D moderate-acting: salbutamol, terbutaline D long-acting: salmeterol, formoterol D Theophyllines: aminophylline D Muscarinic antagonists: ipratropium bromide
Antiasthmatic drugs Bronchodilators Receptor agonists Non-selective：adrenaline, isoprenaline 2-selective: moderate-acting: salbutamol, terbutaline long-acting: salmeterol, formoterol Theophyllines: aminophylline Muscarinic antagonists: ipratropium bromide