Box Actions of angiotensin II Constricting vessels, increase peripheral resistance and returned blood volume Increasing sympathetic tension, promote release of sympathetic transmitter. Stimulating release of aldosterone Inducing expression of c-fos、cmyc、cun rapidly. Activating MAPK and PtK pathway
Box Actions of angiotensin II • Constricting vessels, increase peripheral resistance and returned blood volume. • Increasing sympathetic tension, promote release of sympathetic transmitter. • Stimulating release of aldosterone. • Inducing expression of c-fos、c-myc、c-jun rapidly. • Activating MAPK and PTK pathway
Angll EGFR P. SHC-GRE2-SOS JAK2 RAS PLC MEK STAT PIP +DAG MAPK PKC MAPK Nucleus Cellular respouse: constriction, migration, growth and hypertroply 图27-1心肌PC的信号系统 AT1、a、ET受体与G4蛋白耦联,PC裂解PP2生成iP2、DAG
AngII AngII
B. Angiotensin converting enzyme inhibitors (ACED and angiotensin receptor antagonists Cardiovascular effects Decrease resistance of peripheral vessels Dilate coronary artery, increase blood supply of heart and kidney, improve cardiac and renal function Reverse myocardial hypertrophy and ventricular remodeling
Cardiovascular effects Decrease resistance of peripheral vessels Dilate coronary artery, increase blood supply of heart and kidney, improve cardiac and renal function Reverse myocardial hypertrophy and ventricular remodeling B. Angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor antagonists
B. Angiotensin converting enzyme inhibitors (ACED and angiotensin receptor antagonists 100 2. Clinical uses 8 Placebo (1 CHF increase motor tolerance Enalap川 decrease mortality 20 (2)Hypertension 036912 Time Months)
B. Angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor antagonists 2. Clinical uses (1) CHF increase motor tolerance decrease mortality (2) Hypertension
B. Angiotensin converting enzyme inhibitors (ACED and angiotensin receptor antagonists 3. Adverse effects Hypotension Cough and angioedema Hyperpotassemia Contraindications: pregnancy and stenosis of renal artery
3. Adverse effects Hypotension ◼ Cough and angioedema ◼ Hyperpotassemia ◼ Contraindications: pregnancy and stenosis of renal artery B. Angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor antagonists