REGENERATIVE NODULES these occur in micro and macro nodular cirrhosis they arise in the midst of scars favored by the rich arterial blood of scar tissue. they are round nodules with a fibrous pseudo capsule with bile ductules due to obstruction of bile flow. they have embryonal type of cell plates. they often show focal cholestasis. they may undergo dysplastic and malignant changes. *they compress the vessels of the capsule contributing to the perpetuation of the cirrhosis
REGENERATIVE NODULES: •these occur in micro and macro nodular cirrhosis. •they arise in the midst of scars favored by the rich arterial blood of scar tissue. •they are round nodules with a fibrous pseudo capsule with bile ductules due to obstruction of bile flow. •they have embryonal type of cell plates. •they often show focal cholestasis. •they may undergo dysplastic and malignant changes. •they compress the vessels of the capsule contributing to the perpetuation of the cirrhosis
病理 大体形态 肝逐渐变形、变硬 变小、包膜增厚、 结节出现而致肝硬 化
大体形态 肝逐渐变形、变硬 变小、包膜增厚、 结节出现而致肝硬 化。 病理
组织学改变 假小叶形成
组织学改变 假小叶形成
病理分型 1.小结节性结节 的直径3-5mm,< 1cm,大小均匀，纤 维间隔较窄，结节 中可有门脉管道。 常见于酒精性肝硬 化
1．小结节性 结节 的直径3-5mm,＜ 1cm，大小均匀，纤 维间隔较窄，结节 中可有门脉管道。 常见于酒精性肝硬 化。 病理分型
病理 2.大结节性结 节直径大小不等 13cm,大者直径 可达5cm,结节 由纤维隔分开， 其中可含正常肝 小叶。多见于肝 炎后肝硬化
2．大结节性 结 节直径大小不等 1-3cm，大者直径 可达5cm，结节 由纤维隔分开， 其中可含正常肝 小叶。多见于肝 炎后肝硬化。 病理