CIRRHOSIS/of LIVER Xiaohong Tao The First Affiliated Hospital Chongqing University of Medical Sciences
CIRRHOSIS of LIVER Xiaohong Tao The First Affiliated Hospital Chongqing University of Medical Sciences
Introduction 种或几种病因长期或反复作用引起的慢性进行性肝 病的后期阶段。(t's the end result of hepatocellular injury resulted from different causes,ERLD 病理—有广泛肝细胞变性坏死、肝细胞结节性再生、 结缔组织增生及纤维化，正常肝小叶结构破坏和假小 叶形成、肝逐渐变形、变硬。The histologic feature is degeneration,regeneration(nodular)and fibrosis. According to the following sequence: INJURY DEGENERATION and necrosis regeneration FIBROSIS FORMATION OF FIBRO-VASCULAR MEMBRANES PARENCHYMAL DISSECTION INTO NODULES REARRANGEMENT OF BLOOD CIRCULATION CIRRHOSIS REARRANGEMENT OF BLOOD CIRCULATION CIRRHOSIS
Introduction 一种或几种病因长期或反复作用引起的慢性进行性肝 病的后期阶段。(It’s the end result of hepatocellular injury resulted from different causes, ERLD ) • 病理—有广泛肝细胞变性坏死、肝细胞结节性再生、 结缔组织增生及纤维化，正常肝小叶结构破坏和假小 叶形成、肝逐渐变形、变硬。The histologic feature is degeneration, regeneration(nodular) and fibrosis. • According to the following sequence: INJURY DEGENERATION and necrosis regeneration FIBROSIS FORMATION OF FIBRO-VASCULAR MEMBRANES PARENCHYMAL DISSECTION INTO NODULES REARRANGEMENT OF BLOOD CIRCULATION CIRRHOSIS REARRANGEMENT OF BLOOD CIRCULATION CIRRHOSIS
Introduction 临床一肝功能损害和门脉高压为主、晚期常出现消 化道出血、肝性脑病等并发症。(The clinical manifestations can be broadly classified into those resulting from hepatocellular dysfunction,such as jaundice and coagulopathy and portal hypertension. The complication often appear in late phase,such as hemmorrage,hepatic encephalopathy. 世界性疾病，所有种族、不论国籍、年龄或性别、 均可罹患。 年龄35~48岁最多，男：女为3.6~8：1
Introduction • 临床— 化道出血、肝性脑病等并发症。(The clinical manifestations can be broadly classified into those resulting from hepatocellular dysfunction, such as jaundice and coagulopathy and portal hypertension. The complication often appear in late phase, such as hemmorrage, hepatic encephalopathy. • 世界性疾病，所有种族、不论国籍、年龄或性别、 均可罹患。 • 年龄35～48岁最多，男：女为3．6～8：1
Introduction Cirrhosis is the third most common cause of death,after heart disease and cancer.killing about 25,000 people each year
Cirrhosis is the third most common cause of death, after heart disease and cancer. killing about 25,000 people each year. Introduction
HISTORY In 1761,This peculiar transformation of the liver was identified by the first anatomic pathologist,Gianbattista Morgagni in his 500 autopsies
HISTORY In 1761, This peculiar transformation of the liver was identified by the first anatomic pathologist, Gianbattista Morgagni in his 500 autopsies