PATHOLOGY Classification of cirrhosis According to World Health Orginization (Anthony P.P.et al,J.Clin.Pathol.31:395,1978) ●MORPHOLOGIC: Macronodular Micronodular Mixe HISTOLOGIC:Portal,Post-necrotic,Post Hepatitic,Biliary,Congestive ETIOLOGIC AGENTS:Genetic,Toxic, Infectious,Biliary,Vascular,Cryptogenic
PATHOLOGY Classification of cirrhosis According to World Health Organization (Anthony P.P. et al. J.Clin.Pathol. 31:395,1978) MORPHOLOGIC: Macronodular Micronodular Mixe HISTOLOGIC: Portal, Post-necrotic, Post Hepatitic, Biliary, Congestive ETIOLOGIC AGENTS: Genetic, Toxic, Infectious, Biliary, Vascular, Cryptogenic
MACRONODULAR CIRRHOSIS:Larger nodules separated by wider scars and irregularly distributed throughout the liver usually due to an infectious agent such as vial hepatitis which does not diffuse uniformly throughout the hver
MACRONODULAR CIRRHOSIS: Larger nodules separated by wider scars and irregularly distributed throughout the liver usually due to an infectious agent such as viral hepatitis which does not diffuse uniformly throughout the liver
DISSECTION NODULES *contain remnants of portal tracts an central veins. are separated by wide scars but contain thin fibrous septa. .contain dilated sinusoids especially at their periphery looking like multiple central veins obviously produced by the inflow of arterial blood coming from the surrounding wide scars. the portal tracts within large nodules may be hypoplastic containing portal venule and arteriole but no bile ducts giving the impression of a disappearing bile duct disorder. *within wide scars regenerative nodules may develop
DISSECTION NODULES: •contain remnants of portal tracts an central veins. •are separated by wide scars but contain thin fibrous septa. •contain dilated sinusoids especially at their periphery looking like multiple central veins obviously produced by the inflow of arterial blood coming from the surrounding wide scars. •the portal tracts within large nodules may be hypoplastic containing portal venule and arteriole but no bile ducts giving the impression of a disappearing bile duct disorder. •within wide scars regenerative nodules may develop