Lipid Bilayer HBsAg Protein -Core:HBcAg 二十面体表壳 小表面蛋白 6%s 大表面蛋白 PS2P091) Hepatitis B virus 2002 James A.Perkins
ETIOLOGY 2.Alcohol abuse 14 e 3.Bile duct obstruction (PBC,PSC) ● 4.Exposure to certain chemicals Use of certain drugs (CC14)13 ● 5.Persistent obstruction to outflow of blood from the liver (such as occurs in the Budd-Chiari syndrome) Heart and blood vessel disturbances
ETIOLOGY 2.Alcohol abuse 14 3. Bile duct obstruction (PBC, PSC) 4. Exposure to certain chemicals Use of certain drugs (CCI4) 13 5.Persistent obstruction to outflow of blood from the liver (such as occurs in the Budd-Chiari syndrome) Heart and blood vessel disturbances
ETIOLOGY 6.Hereditary disease, High blood tyrosine levels at birth (congenital tyrosinosis) Glycogen storage disease Alpha1 antitrypsin deficiency Hereditary accumulation of too much copper (Wilson's disease) e 7.Autoimmune diseases (including autoimmune chronic hepatitis)12 8.Schistosoma hematobium
ETIOLOGY 6. Hereditary disease, High blood tyrosine levels at birth (congenital tyrosinosis) Glycogen storage disease , Alpha1- antitrypsin deficiency Hereditary accumulation of too much copper (Wilson's disease) 7. Autoimmune diseases (including autoimmune chronic hepatitis) 12 8. Schistosoma hematobium
CAUSES lron overload (hemochromatosis) 9.Unknown NASH,Cryptogenic)
CAUSES Iron overload (hemochromatosis) 9. Unknown ( NASH, Cryptogenic)
发病机制 Stellate cell,extracellular matri Normal Liver Injured Liver Hepatocyte Loss of hepatocyte microvilli Doposition Space of Disse Quiescent of scar matrix stellate cell Activated stellate cell Endothelial Loss of Kupffer cell fenestrae Kupffer cell cell activation Hepatic sinusoid
发病机制 Stellate cell, extracellular matrix