Invasive Mole
GTD 1 Invasive Mole
IntroductionDefinition:Invasive molemeans the hydatidiformmole invade the uterine myometrium ormetastasizeto extrauterinetissueBiologicbehavior:Invasivemolevillusmayinvademyometrium or blood vessels or both, atitbeginningspreadlocally,invadethemyometrium,sometimespenetrateuterine wall and spread to the broad ligamentorabdominal cavityGTD2
GTD 2 Introduction • Definition: Invasive mole means the hydatidiform mole invade the uterine myometrium or metastasize to extrauterine tissue. • Biologic behavior: Invasive mole villus may invade myometrium or blood vessels or both, at beginning it spread locally,invade myometrium, sometimes penetrate the uterine wall and spread to the broad ligament or abdominal cavity
PathologyMacro examination:Different size of visculainmyometrium,there may be or may not beprimary focus in uterine cavity.when theinvasion is near serosal layer....Microexamination:Villose structure and trophoblastic cellsproliferation and differentiationdeficiency.villose and trophoblastic cells canbe found in most patients,and cause vascularwall necrosis and bleeding.GTD3
GTD 3 Pathology • Macro examination: Different size of viscula in myometrium,there may be or may not be primary focus in uterine cavity.when the invasion is near serosal layer. • Microexamination: Villose structure and trophoblastic cells proliferation and differentiation deficiency.villose and trophoblastic cells can be found in most patients,and cause vascular wall necrosis and bleeding
Clinical Manifestation.irregular vaginal bleedinguterine subinvolutionthecaluteindoescyst（notdisappear after emptying uterusabdominal painmetastatic focus manifestationGTD
GTD 4 Clinical Manifestation • irregular vaginal bleeding • uterine subinvolution • theca lutein cyst does not disappear after emptying uterus • abdominal pain • metastatic focus manifestation
Diagnosishistory and clinical manifestationsuccessive measurement of HcGultrasound examination.X-rayandCThistologicdiagnosisGTD
GTD 5 Diagnosis • history and clinical manifestation • successive measurement of HCG • ultrasound examination • X-ray and CT • histologic diagnosis