Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
IntroductionJten.Definition:力RDvary- polycysticsyndromeovary(PCos) is a generic descriptionfor a broad spectrum of clinicalUrethralopeningand morphological findings inVaginawithendocrineanwomendysfunction,specificallyabnormal androgennproductionDeaylaandmetabolism
Introduction • Definition: – polycystic ovary syndrome (PCOS) is a generic description for a broad spectrum of clinical and morphological findings in women with an endocrine dysfunction, specifically abnormal androgen production and metabolism
IntroductionUtenuPCoS was firstidentifiedbySteinOand Leventhal in 1935 so that itDvarycan also be knownSteinasLeventhal SyndromeUrethralopeningVaginaFaliepiartiteDearyia
Introduction • PCOS was first identified by Stein and Leventhal in 1935 so that it can also be known as Stein – Leventhal Syndrome
Etiology& PathopysiologyJtenWhat we think we know"Viciouscycle"DvaryAbnormalgonadotropinsecretionExcessLHandlow,tonicFSHUrethralopeningHypersecretionofandrogensVagina- Disrupts follicle maturationSubstrateforperipheralaromatizationFallopinDeayNegativefeedbackonpituitaryay-Decreased FSH secreationnInsulinresistance,Elevatedinsulinlevels
Etiology & Pathopysiology What we think we know. • “Vicious cycle” • Abnormal gonadotropin secretion – Excess LH and low, tonic FSH • Hypersecretion of androgens – Disrupts follicle maturation – Substrate for peripheral aromatization • Negative feedback on pituitary – Decreased FSH secreation • Insulin resistance, Elevated insulin levels
PathologyOvaries:enlarged and/orpolycysticovariesEndometrium: Lack of ovulation foran extended period of time maycause excessive thickening of theendometrium (the lining of theuterus)
Pathology • Ovaries: enlarged and/or polycystic ovaries • Endometrium: Lack of ovulation for an extended period of time may cause excessive thickening of the endometrium (the lining of the uterus)