Collagenic op o plsgue wA wall d-ichcor Endosteum Arterial wall hypertrophy and sclerosis
Arterial wall hypertrophy and sclerosis
B Classification of Antihypertensive Drugs u Diuretics 0 Calcium channel blockers u Regin-angiotensin system inhibitors o Sympathetic inhibitors u Vasodilators
Diuretics Calcium channel blockers Regin-angiotensin system inhibitors Sympathetic inhibitors Vasodilators B. Classification of Antihypertensive Drugs
血管运动中枢 Vasomotor ceter Methyldopa Clonidine 交感神经末梢 Guanabenz Guanethidine Sites of Guanadrel action of 交感神经节 pathetic gangla the major r ol he Propranolol and classes of other B-blockers antihyperte s of vess Prazosin and hydralazine Verapami and oth Losartan and other a, blockers calcium chane nsive drugs Nitroprusside blockers REceptors of juxtaglomerular Kidney tub celis Pnad release renin Thiazides Propranolol and other B blockers 肾小球旁细胞 converting enzyme Alkire other ACE inhbitors
血管运动中枢 交感神经末梢 交感神经节 肾小球旁细胞 Sites of action of the major classes of antihyperte nsive drugs
C. Antihypertensive Drugs Diuretics 1. Pharmacologicaleffects ()Reducing plasma volume (cardiac output l) (2) Reducing Na*-Ca2* exchange in vascular smooth muscle cells(Ca2+i L, peripheral resistance l)
Diuretics 1. Pharmacological effects (1) Reducing plasma volume (cardiac output ) (2) Reducing Na+ -Ca2+ exchange in vascular smooth muscle cells (Ca2+ i , peripheral resistance ) C. Antihypertensive Drugs
Thiazide diuretics Sodium water retention Nat- Ca2+ exchange 个 Cai 2+ Blood in vascular volume smooth muscle cels Peripheral Cardiac resistance output Decrease in blood pressure
Na+ -Ca2+ exchange , Ca2+ i in vascular smooth muscle cells