BIOCHEMISTRYANDMOLECULARBIOLOGYThe Structure of CapCH3HN?OCN鸟嘌岭H2C-CHP0P.OOOOO9OH OHOP.0OCAAA-OH3'Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY The Structure of Cap
BIOCHEMISTRYANDMOLECULARBIOLOGYThefunction of capandpolyAmRNAmove from nucleus to cytosol·Maintain the stability of mRNA.The regulation of translation initiationDepartment of Biochemistryand Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY The function of cap and polyA •mRNA move from nucleus to cytosol •Maintain the stability of mRNA •The regulation of translation initiation
BIOCHEMISTRYANDMOLECULARBIOLOGY*FunctionofmRNACarry DNA genetic information transferto ribosome determining the amino acidsequence of proteinProkaryoteEukaryotenucleuSintronexonDNADNATranscriptionTranscriptionhnRNAmRNASplicingandtransferTranslationmRNAProteinTranslation蛋白neSchoolDepartmentofBiochemistryandMolecul
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY *Function of mRNA Carry DNA genetic information transfer to ribosome determining the amino acid sequence of protein DNA mRNA Protein Transcription Translation Prokaryote nucleus DNA intron exon Transcription Splicing and transfer mRNA hnRNA Translation 蛋白 Eukaryote
BIOCHEMISTRYANDMOLECULARBIOLOGY3.TheStructureandFunctionoftRNA* Primary structure of tRNA> Contain 10~20% rare base, such as DHU> 3'end is CCA-OH>Most of 5end is G> Contain TyCDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY 3. The Structure and Function of tRNA * Primary structure of tRNA ➢ Contain 10~20% rare base, such as DHU ➢ 3´end is — CCA-OH ➢ Most of 5´ end is G ➢ Contain TC
BIOCHEMISTRYANDMOLECULARBIOLOGY00Rare baseHNNH/H-NHCH3NHHNNHHCH3Dihydrogen uracilN,N dimethyl guanineS0NNNHNHNNH0InosineDepartment of Biochemistry and Moeulfthydryl.uraclicineSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY N NH NH N N O CH3 CH3 NH NH O O H H H H NH NH S O Rare base N,N dimethyl guanine Dihydrogen uracil Inosine 4-sulfhydryl uracil