0 0-P-0C 000c ATP ADP 0-P-0-CHe o CH2-0-P-0 0 H HO H HO phosphofructokinase-1 OHH磷酸果糖激酶-1OHH Fructose 6-phosphate Fructose 1, 6-bisphosphate 关键酶 △G°=-142kJ/mol
16 磷酸果糖激酶-1 关键酶
GLUCOSE CH, OH OH HO ATP 己糖激酶/葡萄糖激酶 ADP LUCOSE 6-P CH,-0-P OH OH (2)磷酸己糖异构酶 _磷酸果糖激酶1 FRUCTOSE 1, 6-Pa oH2c、oH H,OH (3) ATP ADP
17 己糖激酶/葡萄糖激酶 磷酸己糖异构酶 磷酸果糖激酶-1 ATP ADP ATP ADP * * (1) (2) (3)
2.裂解( lysis)—磷酸丙糖的生成: 分子F-1,6-BP裂解为两分子可以互 变的磷酸丙糖( triose phosphate), 包括两步反应: (4)F-1,6-BP裂解为3-磷酸甘油醛 ( glyceraldehyde-3- phosphate)和磷 酸二羟丙酮( dihydroxyacetone phosphate, DHAP (5)磷酸二羟丙酮异构为3-磷酸甘油醛
18 2.裂解(lysis)——磷酸丙糖的生成: ⚫ 一分子F-1,6-BP裂解为两分子可以互 变的磷酸丙糖(triose phosphate), 包括两步反应: ⑷ F-1,6-BP 裂 解 为 3- 磷 酸 甘 油 醛 (glyceraldehyde-3-phosphate) 和 磷 酸二羟丙酮 (dihydroxyacetone phosphate, DHAP); ⑸ 磷酸二羟丙酮异构为3-磷酸甘油醛
0 0-P-0-CH2 CH2-0-P-0 CH2-0-P-0 0 0 HCOH 0 H HO OH aldolase CH2-0P-0 CHOO OH H 醛缩酶 0 Fructose 1, 6-bisphosphate Dihydroxyacetone Glyceraldehyde phosphate 3-phosphate △G°=238kJ/mol
19 醛缩酶
0.H CHOH C=00 HCOH triose phosphate Isomerase CH2-0-P-0 CH2-0-P-0 磷酸丙糖 异构酶 Di hydroxyacetone Glyceraldehyde phosphate 3-phosphate △G°=7.5 k/mol
20 磷酸丙糖 异构酶