LDL receptor . The LDL receptor is central to cholesterol homeostasis (1970s Brown and Goldstein) When LDL binds to its receptor via recognition of the apoprotein B100) the entire LDL molecule is taken up (engulfed) by the cell in clatherin coated pits- endosomes lysosomes
•The LDL receptor is central to cholesterol homeostasis (1970’s Brown and Goldstein) • When LDL binds to its receptor (via recognition of the apoprotein B100) the entire LDL molecule is taken up (engulfed) by the cell in clatherin coated pits endosomes lysosomes LDL receptor
Physiologic role of cholesterol Component of all cell membranes Precursor of other steroids Cortisol(糖皮质激素) Progesterone(孕酮) Estrogen(雌激亲) Testosterone(睾酮) · Bile acids(胆汁酸) Excess cholesterol and/or triglyceride - Hyperlipmia(高脂血症)or hyperlipoproteinemia(高脂蚕白血症) Atherosclerosis(动脉粥枰硬化) Coronary heart disease(CHD) -× anthomas(黄瘤)
• Physiologic Role of Cholesterol – Component of all cell membranes – Precursor of other steroids • Cortisol(糖皮质激素) • Progesterone(孕酮) • Estrogen(雌激素) • Testosterone(睾酮) • Bile acids(胆汁酸) • Excess cholesterol and/or triglyceride – Hyperlipmia (高脂血症) or hyperlipoproteinemia (高脂蛋白血症) – Atherosclerosis (动脉粥样硬化) – Coronary heart disease (CHD) – Xanthomas (黄瘤)
表27-1高脂蛋白血症的分型 分型 脂蛋白变化 脂质变化 CM↑ TC TG↑↑↑ LDL↑ TC↑↑ ‖ⅢⅣv VLDL、LDL↑ TCT↑TG↑↑ IDL↑ TC↑↑TG↑↑ VLDL↑ TG↑↑ CM、VLDL↑ TC↑ TOft
Simple classification of Hy perlipidemias TC TG Hypercholestrolemia↑ 高胆固醇血症 Hypertriglyceridemia 高油三酷血症 Mix Hyperlijpidem旧a 混合型高脂血症
TC TG Hypercholestrolemia 高胆固醇血症 ↑ Hypertriglyceridemia 高甘油三酯血症 ↑ Mix Hyperlipidemia 混合型高脂血症 ↑ ↑ Simple Classification of Hyperlipidemias
B Increased vascular tone (for example, during exercise) 50% obstruction 70% Obstruction Potential for angIna Exercise-induced angina A Frank vasospasm C Decreased vascular tone (for example, with use of vasodilators) 99% Obstruction Resting angina 30% Obstruction Blood flow in a coronary artery No angina partially ly blocked with atherosclerotic plaques