2.The effects of glucocorticoids(Anti-inflammation,Immunosuppression,Antitoxic action,Anti- shock,Hematologic effects,Enfluence on the blood cells,the central nervous system,the digestive system,the metabolism and so on),indications(Adrenal cortical insufficiency,Severe acute infection,All kinds of shock, Prevention of inflammation of vital organs,Immune disease,Allergic diseases,Hemopathy,Skin disease and so on )advsese reactions(Hypercorticoidism,induce or aggravate infection,peptic ulcer,osteoporosis,delay the healing of wound,delay of growth,adrenal atrophy and cortical insufficiency,psychosis,rebound phenomenon and so on )contraindications,usage and course of treatment. 3.ACTH,the characteristic of major effects 【Time planed:3h】 6.2 Drugs wsed for diabetes mellitus 【Purposes and Demands】 Be familiar with the effects,mechanism,indications and the major adverse reactions of Insulin, Sulphonylureas,Biguanides. 【teaching content】 1.The effects,indications and the adverse reactions of Insulin.The characteristics of several Insulin preparations. 2.Oral antidiabetic drugs:the effects,mechanism,indications and the adverse reactions of Sulphonylureas and Biguanides.The effects and the indication of Acarbose(a-glucosidase inhibitor) 【Time planed:1.5h】 PartⅢChemotherapy 7 Infectious Disease 7.1 principles of bacterial chemotherapy 【Purposes and Demands】) Master the concept of antibacterial spectrum,antibacterial activity,bacterial resistance,and the mechanism of antibacterial activity.Understand the rational application of antibiotics.. 【Teaching Content] 1.the concept and medical terms of chemotherapeutic drugs (antibacterial spectrum,antibacterial activity, resistance,chemotherapeutic index) 2.the action mechanism of antibiotics: Inhibit the metabolism of folic acid:sulfonamides and TMP Affect the metabolism of nucleic acid: Quinolones,Rifampicin Inhibition of protein synthesis:aminoglycosides,lincomycins,Tetracyclins, Chloramphenicol. Inhibition of the bacterial cell wall synthesis:Cephalosporins,Penicillins 3.bacterial resistance to drugs 4.the principles of antibiotics rational application 5.Single use or combination therapy 【Time planed:1hl 7.2 Antibacterial Drugs(Penicillins and Cephalosporins.) 【purpose and desire] To master the action,mechanism of action,indications,major ADR,prophylaxis and cure of ADR about Penicillins.To be familiar with the antibacterial characteristics and uses of semi-synthetic-Penicillins,and -29-
- 29 - 2. The effects of glucocorticoids(Anti- inflammation, Immunosuppression , Antitoxic action, Antishock, Hematologic effects, Enfluence on the blood cells, the central nervous system, the digestive system, the metabolism and so on), indications (Adrenal cortical insufficiency, Severe acute infection, All kinds of shock, Prevention of inflammation of vital organs, Immune disease, Allergic diseases, Hemopathy, Skin disease and so on ), advsese reactions ( Hypercorticoidism, induce or aggravate infection, peptic ulcer, osteoporosis, delay the healing of wound, delay of growth, adrenal atrophy and cortical insufficiency, psychosis, rebound phenomenon and so on ), contraindications, usage and course of treatment . 3.ACTH, the characteristic of major effects 【Time planed: 3h】 6.2 Drugs wsed for diabetes mellitus 【Purposes and Demands 】 Be familiar with the effects, mechanism, indications and the major adverse reactions of Insulin, Sulphonylureas, Biguanides. 【teaching content】 1. The effects, indications and the adverse reactions of Insulin. The characteristics of several Insulin preparations。 2. Oral antidiabetic drugs: the effects, mechanism, indications and the adverse reactions of Sulphonylureas and Biguanides. The effects and the indication of Acarbose (α-glucosidase inhibitor ) 【Time planed: 1.5h】 Part Ⅲ Chemotherapy 7 Infectious Disease 7.1 principles of bacterial chemotherapy 【Purposes and Demands】 Master the concept of antibacterial spectrum, antibacterial activity, bacterial resistance, and the mechanism of antibacterial activity . Understand the rational application of antibiotics.. 【Teaching Content】 1.the concept and medical terms of chemotherapeutic drugs（antibacterial spectrum, antibacterial activity, resistance, chemotherapeutic index） 2. the action mechanism of antibiotics : Inhibit the metabolism of folic acid: sulfonamides and TMP Affect the metabolism of nucleic acid: Quinolones, Rifampicin Inhibition of protein synthesis: aminoglycosides, lincomycins, Tetracyclins, Chloramphenicol. Inhibition of the bacterial cell wall synthesis: Cephalosporins, Penicillins 3. bacterial resistance to drugs 4. the principles of antibiotics rational application 5. Single use or combination therapy 【Time planed: 1 h】 7.2 Antibacterial Drugs (Penicillins and Cephalosporins.) 【purpose and desire】 To master the action, mechanism of action, indications, major ADR, prophylaxis and cure of ADR about Penicillins. To be familiar with the antibacterial characteristics and uses of semi-synthetic-Penicillins, and
Cephalosporins. Understand the antibacterial characteristics and indications of some other B-Lactam antibiotics 【teaching content] 1.The physical and chemical properties,pharmacokinetics,antibacterial action, mechanism of action,resistance,uses,ADR(allergic reaction)and prevention and cure of Penicillin 2..The classification,antibacterial characteristics and indications of semi-synthetic-Penicillin. 3.The classification,antibacterial characteristics,indications of Cephalosporins.Preparations of Cephalosporins in common use 4.The antibacterial characteristics and indications of some other B-Lactam antibiotics Time planed:3h】 7.3 Synthetic Antibacterial Drugs(Quinolones and Sulfonamides) 【Purposes and Demands】) To master the action,mechanism,indications,the major adverse reaction of Quinolones,and the action, mechanism,indications,the major adverse reaction and prophylaxis of ADR on Sulfonamides.To be familiar with the action and indications of TMP.To be familiar with the principle which causes synergistic antibacterial effect(TMP and Sulfonamides are combined). To understand the antibacterial characteristics and indications of furans 【Teaching Content】 1.The action,mechanism,indications,the major adverse reaction of Quinolones, 2.The classification and structure-activity relationship of Sulfonamides,antibacterial action,mechanism, resistance,pharmacokinetics,uses,ADR and prevention of ADR about Sulfonamides(renal injury,allergy, reactions of hematopoietic system and so on).Acting characteristics of SD,SMZ,SIZ,SA. 3.The action,indications and ADR of TMP,principle which causes synergistic antibacterial effect(TMP is used in combination with sulfonamides),and the preparations that TMP and Sulfonamides are combined. 4.furans:the actions,uses and ADR of furadantin,furazolidone. 【Time planed:2.5h】 7.4 Lincomycins and Glycopeptides 【Purposes and Demands】 To be familiar with antibacterial characteristics and uses of Lincomycins. To understand antibacterial characteristics of Vancomycin 【Teaching Content] 1.Antibacterial characteristics and indications of Lincomycins. 2.Antibacterial characteristics and indications of Vancomycin 【Time planed:0.5hj 7.5 Aminoglycosides and Polymyxins 【Purposes and Demands】 To master the antibacterial action and mechanism of Aminoglycosides.The characteristics,uses and major ADR of Aminoglycosides drugs in common use.Understand antibacterial characteristics of Polymyxins. 【Teaching Content] 1.The antibacterial action and mechanism of Aminoglycosides 2.Pharmocokinetics,action,mechanism of action,uses and ADR of Gentamicin. 3.The antibacterial characteristics,uses and major ADR of Aminoglycosides in common use. 4.The antibacterial characteristics of Polymyxins. -30-
- 30 - Cephalosporins. Understand the antibacterial characteristics and indications of some other ß-Lactam antibiotics. 【teaching content】 1. The physical and chemical properties ,pharmacokinetics, antibacterial action , mechanism of action ,resistance, uses ,ADR(allergic reaction) and prevention and cure of Penicillin 2..The classification ,antibacterial characteristics and indications of semi-synthetic-Penicillin. 3. The classification ,antibacterial characteristics, indications of Cephalosporins. Preparations of Cephalosporins in common use 4.The antibacterial characteristics and indications of some other ß-Lactam antibiotics 【Time planed: 3h】 7.3 Synthetic Antibacterial Drugs (Quinolones and Sulfonamides ) 【Purposes and Demands】 To master the action, mechanism, indications, the major adverse reaction of Quinolones, and the action, mechanism, indications, the major adverse reaction and prophylaxis of ADR on Sulfonamides. To be familiar with the action and indications of TMP. To be familiar with the principle which causes synergistic antibacterial effect (TMP and Sulfonamides are combined). To understand the antibacterial characteristics and indications of furans. 【Teaching Content】 1. The action, mechanism, indications, the major adverse reaction of Quinolones , 2. The classification and structure-activity relationship of Sulfonamides, antibacterial action, mechanism, resistance, pharmacokinetics, uses, ADR and prevention of ADR about Sulfonamides(renal injury, allergy, reactions of hematopoietic system and so on). Acting characteristics of SD, SMZ, SIZ, SA. 3. The action, indications and ADR of TMP, principle which causes synergistic antibacterial effect (TMP is used in combination with sulfonamides), and the preparations that TMP and Sulfonamides are combined. 4. furans: the actions, uses and ADR of furadantin, furazolidone. 【Time planed: 2.5 h】 7.4 Lincomycins and Glycopeptides 【Purposes and Demands】 To be familiar with antibacterial characteristics and uses of Lincomycins. To understand antibacterial characteristics of Vancomycin 【Teaching Content】 1. Antibacterial characteristics and indications of Lincomycins. 2. Antibacterial characteristics and indications of Vancomycin 【Time planed: 0.5 h】 7.5 Aminoglycosides and Polymyxins 【Purposes and Demands】 To master the antibacterial action and mechanism of Aminoglycosides. The characteristics, uses and major ADR of Aminoglycosides drugs in common use. Understand antibacterial characteristics of Polymyxins. 【Teaching Content】 1. The antibacterial action and mechanism of Aminoglycosides. 2. Pharmocokinetics, action, mechanism of action, uses and ADR of Gentamicin. 3. The antibacterial characteristics, uses and major ADR of Aminoglycosides in common use. 4. The antibacterial characteristics of Polymyxins
【Time planed:2h】 7.6 Tetracyclines and Chloramphenicols 【Purpose and Demands】 To master the antibacterial action,mechanism of action,uses,major ADR,prophylaxis and cure of ADR on Tetracyclines and Chloramphenicols.To master antibacterial characteristics of Doxycycline To understand pharmacokinetics of Tetracyclines, 【Teaching Content】 1.The classification of Tetracyclines 2.The antibacterial action,mechanism of action,Pharmacokinetics,uses and major ADR of Tetracyclines 3.Characteristics of Doxycycline 4.The antibacterial action,mechanism,uses and ADR of Chloramphenicol 【Time planed:1h】 7.7 Drugs for tuberculosis 【Purpose and Demands】 To master the action and uses of Isoniazid,Rifampicin.To be familiar with major ADR of the two drugs.To be familiar with the names of medicines which are the first-line and the second-line drugs used in the treatment of tuberculosis.To understand the characteristics of other antituberculosis drugs and the applied principle of antituberculosis drugs. 【Teaching Content] 1.Classification of the first-line and the second-line drugs for tuberculosis 2.The effect,indications,major ADR,and the prophylaxis and cure of ADR on Isoniazide 3.The pharmacokinetics,effects,indications and ADR of Rifampicin. 4.The effect characteristics of other antituberculosis drugs. 5.The applied principle of antituberculosis drugs. 【Time planed:1h】 -31-
- 31 - 【Time planed: 2 h】 7.6 Tetracyclines and Chloramphenicols 【Purpose and Demands】 To master the antibacterial action, mechanism of action, uses, major ADR, prophylaxis and cure of ADR on Tetracyclines and Chloramphenicols. To master antibacterial characteristics of Doxycycline . To understand pharmacokinetics of Tetracyclines , 【Teaching Content 】 1. The classification of Tetracyclines 2. The antibacterial action, mechanism of action, Pharmacokinetics, uses and major ADR of Tetracyclines 3. Characteristics of Doxycycline 4. The antibacterial action, mechanism, uses and ADR of Chloramphenicol 【Time planed: 1 h】 7.7 Drugs for tuberculosis 【Purpose and Demands】 To master the action and uses of Isoniazid, Rifampicin. To be familiar with major ADR of the two drugs. To be familiar with the names of medicines which are the first-line and the second-line drugs used in the treatment of tuberculosis. To understand the characteristics of other antituberculosis drugs and the applied principle of antituberculosis drugs. 【Teaching Content】 1. Classification of the first-line and the second-line drugs for tuberculosis 2. The effect, indications, major ADR, and the prophylaxis and cure of ADR on Isoniazide 3. The pharmacokinetics, effects, indications and ADR of Rifampicin. 4. The effect characteristics of other antituberculosis drugs. 5. The applied principle of antituberculosis drugs. 【Time planed: 1 h】
Teaching Schedule of Pharmacology No. Course Theories class hours 1 Introduction,Pharmacodynamics 3 2 Pharmacokinetics 2 3 Drug interactions and adverse effects 0.5 4 autonomic nerve system,Cholinergics,Anticholine drugs 3 5 Adrenomimetics,Adrenoceptor antagonists 3 6 Sedative hypnotics 1.5 7 Psychotolytics. 1.5 8 Analgesics 2 9 Antihypertensive drugs 2.5 10 Drugs for congestive heart failure 2 11 Antianginal drugs 1.5 12 Antiarrhythmic drugs 1.5 13 Diuretics 2.5 14 Adrenal corticosteroids 3 15 Drugs for diabetes 1.5 16 Antibiotics(1) 3 17 Antibiotics(2) 3 18 Antibiotics(3) 3 19 Chemotherapy 2 20 Total 42 Textbooks and references 1.Golan DE,et al.Principle of Pharmacology,The pathophysiologic basis of drug therepy.2 edition, 2008,Lippincott Williams &Wilkins. 2.Farrell SE.The workbook of Principles of Pharmacology.2d edition.2008,Lippincott Williams &Wilkins. 3.Laurence L.Brunton.Goodman &Gilman's The Pharmacological Basis of Therapeutics.Twelfth edition,2011,McGraw-Hill Company. 4.药理学(Pharmacology),娄建石主编，清华大学出版社，2015年7月，第一版。 【校内学习平台和网络资源】 htp:/pkc.shutcm.com/②yyx/全英语教学 -32-
- 32 - Teaching Schedule of Pharmacology No. Course Theories class hours 1 Introduction,Pharmacodynamics 3 2 Pharmacokinetics 2 3 Drug interactions and adverse effects 0.5 4 autonomic nerve system, Cholinergics , Anticholine drugs 3 5 Adrenomimetics, Adrenoceptor antagonists 3 6 Sedative hypnotics 1.5 7 Psychotolytics, 1.5 8 Analgesics 2 9 Antihypertensive drugs 2.5 10 Drugs for congestive heart failure 2 11 Antianginal drugs 1.5 12 Antiarrhythmic drugs 1.5 13 Diuretics 2.5 14 Adrenal corticosteroids 3 15 Drugs for diabetes 1.5 16 Antibiotics(1) 3 17 Antibiotics(2) 3 18 Antibiotics(3) 3 19 Chemotherapy 2 20 Total 42 Textbooks and references 1.Golan DE，et al. Principle of Pharmacology, The pathophysiologic basis of drug therepy. 2nd edition, 2008 ,Lippincott Williams &Wilkins. 2.Farrell SE. The workbook of Principles of Pharmacology. 2nd edition. 2008, Lippincott Williams &Wilkins. 3.Laurence L. Brunton. Goodman &Gilman’s The Pharmacological Basis of Therapeutics. Twelfth edition, 2011, McGraw-Hill Company. 4. 药理学（Pharmacology），娄建石主编，清华大学出版社，2015 年 7 月，第一版。 【校内学习平台和网络资源】 http://jpkc.shutcm.com/zyylx/ 全英语教学
《药理学》教学大纲 一、课程一般信息 课程编号：03.022.5.1 课程名称：药理学 开课学院：中药学院 课程类型：必修课 学分：3学分 学时：42学时 前期课程：解剖学，生理学，病理学，生物化学、微生物与免疫学等 授课对象：中医学专业七年制、中医基础专业七年制 二、课程基本要求（或课程简介） 药理学是研究药物和机体相互作用的一门科学，主要研究内容是药物的药效动力学和药代动力学。 总论部分介绍药理学的基本概念和药物的作用规律，各论部分介绍作用于外周神经系统、中枢神经系统、 内脏系统以及自体活性物质、激素类、抗病原微生物等药物的药理作用、用途和不良反应，为临床合理 用药、充分发挥药物的防治作用和防止不良反应提供理论依据。药理学是医学培养的重要内容。在教学 中我们将重视培养学生解决问题、分析问题的能力。 课程由之前的板书等教学形式逐步转变为PPT、教学录像、分组讨论等教学形式，在教学过程中， 结合中医学七年制学生专业背景，采用以“问题为导向”、“案例教学”等多种教学方法，引导学生运用 药理学知识解决临床实际问题，注重培养学生对药理学课程的学习兴趣，加强学生对重要知识点的理解 与掌握。 Pharmacology is a science which studies the interactions between drugs and organisms,mainly about Pharmacodynamics and Pharmacokinetics.The introduction part deals with the basic concept and mechanisms of the drugs.The specialized part introduce the structure-function relationship,intracorporal process, pharmacological action,effect and adverse effect of the drugs that act on Peripheral Nervous Systems,Central Nervous System and visceral System.Included are also some other drugs,such as autoallergic active compound, hormones,anti-pathogens,anti parasitic diseases,anti-carcinoma and so on.The teaching method of the course is composed of PPT,teaching video,group discussion and other teaching forms.In addition,combined with the professional background of the students,multiple teaching methods,such as"problem-oriented","case teaching" and so on are used.The main objective of the course is to guide students to use pharmacological knowledge to solve clinical problems. 三、教学大纲内容 （一）课程总体目标 通过本课程学习，帮助学生学习常用药物的药理作用、临床用途、不良反应及禁忌证，提高学生对 临床药物选择和应用能力：帮助学生掌握常用药物作用、作用机制、临床应用、不良反应及禁忌等技能， 培养学生针对疾病合理使用药物，提高学生运用所学药理学知识分析临床用药的基本方法，以更好地提 高解决临床实际问题的能力，逐步建立正确的药理学科研思路与方法。同时，通过对代表药物的系统讲解， 及其在现代医学中的应用，激发学生学习专业知识的热情，调动学生学习主观能动性和积极性，坚定学 生学习专业的信念，增强学生传承中医药文化的责任心。 -33-
- 33 - 一、课程一般信息 课程编号 ：03.022.5.1 课程名称 ：药理学 开课学院 ：中药学院 课程类型 ：必修课 学分 ： 3 学分 学时 ： 42 学时 前期课程 ：解剖学，生理学，病理学，生物化学、微生物与免疫学等 授课对象 ：中医学专业七年制、中医基础专业七年制 二、课程基本要求（或课程简介） 药理学是研究药物和机体相互作用的一门科学，主要研究内容是药物的药效动力学和药代动力学。 总论部分介绍药理学的基本概念和药物的作用规律，各论部分介绍作用于外周神经系统、中枢神经系统、 内脏系统以及自体活性物质、激素类、抗病原微生物等药物的药理作用、用途和不良反应，为临床合理 用药、充分发挥药物的防治作用和防止不良反应提供理论依据。药理学是医学培养的重要内容。在教学 中我们将重视培养学生解决问题、分析问题的能力。 课程由之前的板书等教学形式逐步转变为 PPT、教学录像、分组讨论等教学形式，在教学过程中， 结合中医学七年制学生专业背景，采用以“问题为导向”、“案例教学”等多种教学方法，引导学生运用 药理学知识解决临床实际问题，注重培养学生对药理学课程的学习兴趣，加强学生对重要知识点的理解 与掌握。 Pharmacology is a science which studies the interactions between drugs and organisms，mainly about Pharmacodynamics and Pharmacokinetics. The introduction part deals with the basic concept and mechanisms of the drugs. The specialized part introduce the structure-function relationship, intracorporal process , pharmacological action, effect and adverse effect of the drugs that act on Peripheral Nervous Systems, Central Nervous System and visceral System. Included are also some other drugs, such as autoallergic active compound, hormones, anti-pathogens, anti parasitic diseases, anti-carcinoma and so on. The teaching method of the course is composed of PPT, teaching video, group discussion and other teaching forms. In addition, combined with the professional background of the students, multiple teaching methods, such as "problem-oriented", "case teaching" and so on are used. The main objective of the course is to guide students to use pharmacological knowledge to solve clinical problems. 三、教学大纲内容 （一）课程总体目标 通过本课程学习，帮助学生学习常用药物的药理作用、临床用途、不良反应及禁忌证，提高学生对 临床药物选择和应用能力 ；帮助学生掌握常用药物作用、作用机制、临床应用、不良反应及禁忌等技能， 培养学生针对疾病合理使用药物，提高学生运用所学药理学知识分析临床用药的基本方法，以更好地提 高解决临床实际问题的能力，逐步建立正确的药理学科研思路与方法。同时，通过对代表药物的系统讲解， 及其在现代医学中的应用，激发学生学习专业知识的热情，调动学生学习主观能动性和积极性，坚定学 生学习专业的信念，增强学生传承中医药文化的责任心。 《药理学》教学大纲