基因分子细胞多层次整体群体DepartmentofimrsXi'an.liaotongUniversity
Department of Immunology and Pathogen Biology, School of Medicine, Xi’an Jiaotong University 多层次 分子 细胞 整体 群体 基因
一、基因水平的免疫调节MHC对免疫应答遗传控制BCR、TCR特异性（基因重排）DenartmentofinliantongUniversit
Department of Immunology and Pathogen Biology, School of Medicine, Xi’an Jiaotong University 一、 基因水平的免疫调节 MHC对免疫应答遗传控制 BCR、TCR特异性（基因重排）
二、 分子水平的免疫调节（一）抗原调节Ag个→刺激Ag→抑制（回复）DepartmentofimrXi'anliaotongUniversity
Department of Immunology and Pathogen Biology, School of Medicine, Xi’an Jiaotong University （一）抗原调节 Ag →刺激 Ag →抑制（回复） 二、 分子水平的免疫调节
（二）Ab和Ag-Ab复合物的调节1.Ab的反馈调节抗BCR抗体，Ag-Ab复合物受体交联FeRBBAb个→抑制Ab产生ITIMAb→促进Ab产生TC-PTHSHP.1SHIPPTR磷酸化PLCVavSYK-PTK★去硝酸化*+招募PTPSy+阻断/抑制B维胞活化抑制性受体FcyRIⅡI-B的作用DepartmentofimXi'anJiaotongUniversity
Department of Immunology and Pathogen Biology, School of Medicine, Xi’an Jiaotong University （二）Ab和Ag-Ab复合物的调节 1.Ab的反馈调节 Ab →抑制Ab产生 Ab →促进Ab产生
抗Ag-Ab复合物的IgG介导抑制抗IgMR的gG介导抑制Ag-Ab复合物抗ulgGBCRBCRITIMITIMFCYRII-BFC-RII-B一B细胞B细胞抗BCR抗体或抗原抗体复合物交联BCR和FcR-B抑制B细胞增殖Departmentofimmunologyand PathogenBiologySchool ofMedicine,Xi'anJiaotongUniversity
Department of Immunology and Pathogen Biology, School of Medicine, Xi’an Jiaotong University 抗BCR抗体或抗原抗体复合物交联BCR和Fc R-B抑制B细胞增殖