复旦大学：《医学微生物学 Medical Microbiology（MBBS）》课程讲义_理论课_Lecture16-Virus Pathogenesis & Antiviral Defenses

Factors Determine viral Pathogenesis Viral virulence(eg cytopathic effect) Cellular and tissue damages as a result of host antiviral defenses against viruses [eg host defense mediated inflammation(localized or systemic ● Oncogenic factors Viral oncogene Insertion of viral dna in the host chromosome

Factors Determine Viral Pathogenesis z Viral virulence (eg. cytopathic effect) z Cellular and tissue damages as a result of host antiviral defenses against viruses [eg. host defense mediated inflammation (localized or systemic] inflammation (localized or systemic] z Oncogenic factors ¾ Viral oncogene Viral oncogene ¾ Insertion of viral DNA in the host chromosome

Viral virulence o the ability of a virus to cause disease in an infected host (or pathogenicity) e Molecular and genetic determinants of viral virulence are located throughout the viral genome Different strains of the same virus may differ in the degree of virulence Strains have mutated and lost their ability to cause cytopathic effects(CPE) and disease are termed as avirulent or attenuated strains

Viral Virulence z The ability of a virus to cause disease in an infected host (or The ability of a virus to cause disease in an infected host (or pathogenicity) z Molecular olecular and genetic determinants rminants of viral virulence are located throughout the viral genome z Different strains of the same virus may differ in the degree of virulence z Strains have mutated and lost their ability to cause cytopathic eff t (CPE) d di t d i l t ffects (CPE) and disease are termed as avirulent or attenuated strains