Herpesvirus Human Cancer associated viruses Qiliang Cai(蔡启良) MOH&MOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University (复旦大学上海医学院分子病毒学教育部/卫生部重点实验室) 2013-12-09
Herpesvirus & Human Cancer - associated Viruses Qiliang Cai (蔡启良) MOH&MOE Key Lab of Medical Molecular Virology Shanghai Medical College, Fudan University (复旦大学上海医学院分子病毒学教育部/卫生部重点实验室) 2013-12-09
Take-home messages 1. The purpose of viral life is to replicate itself (its associated L pathogenesis or human diseases are secondary effects) 2. Virus utilizes host machinery to replicate (cellular and organal) 3. The ultimate form of parasitization is to co-exist with the host. (at both individual and population levels) 4. Studies of viruses have double meanings (medically important and scientifically interesting) 5. Herpesvirus has two phases of the life cycle latent infection and lytic infection. 6. Which types of HPv are considered"high risk"that may cause pre-cancerous lesions and lead to cervical cancer?
Take-home messages: 1. The purpose of viral life is to replicate itself. (its associated pathogenesis or human diseases are secondary effects) 2. Virus utilizes host machinery to replicate. (cellular and organal) 3. The ultimate form of parasitization is to co-exist with the host. (at both individual and population levels) 4. Studies of viruses have double meanings. (medically important and scientifically interesting) 5. Herpesvirus has two phases of the life cycle: latent infection and lytic infection. 6. Which types of HPV are considered “high risk” that may cause pre-cancerous lesions and lead to cervical cancer?
Herpesvirus 1 Introduction of herpesviruses 2. Herpesviral latency 3. Mechanism of herpesviral replication 4. Oncolytic virotherapy Papillomavirus 1. Characteristics of HPv 2. Epidemiology of genital HPV infection 3. Pathogenesis, Clinical manifestations and sequelae 4. Diagnosis, Treatment Prevention
1. Introduction of herpesviruses 2. Herpesviral latency 3. Mechanism of herpesviral replication 4. Oncolytic virotherapy Herpesvirus Papillomavirus 1. Characteristics of HPV 2. Epidemiology of genital HPV infection 3. Pathogenesis, Clinical manifestations and sequelae 4. Diagnosis, Treatment & Prevention
Changes in cell that are at the roots of cancer Genetic and epigenetic alterations. (Proto-oncogene, tumor suppressor gene, mutator gene) V Mutations Deletions Recombinations Transpositions Epigenetic alterations(DNA methylation, imprinting Acquisition of VirAL genetic material
Changes in cell that are at the roots of cancer Genetic and epigenetic alterations: (Proto-oncogene, tumor suppressor gene, mutator gene) Mutations Deletions Recombinations Transpositions Epigenetic alterations (DNA methylation, imprinting) Acquisition of VIRAL genetic material
Virus←→3040% Human cancers EBV assoc, with Burkitts HTLV-1 and link Lymphoma Discovered to human T-Cell 1st Human Leukemia discovered Tumor Virus (1981) (1965) KSHV and link to Ks ALV HA∨ (1908) (1953-54) Merkel cell Link bet. HBV& Discovered MMTV Hepatocellular (1994) Polyoma Virus link to Merkel Cell Cancer RSV (1936) Carcinoma MPV 2008 (1911) (1953) (1975) Link bet. hcv CRPV SV40 Link bet. HPV& Hepatocellular FDA approves use HPV (1960) Cervical Cancer Carcinoma of HPv vaccine (1907) (1933) MLV (1951) (1974-1984) (1989) for cervical cancer (2006) 19101920193019401950196019701980199020002010 Timeline of Advances on Tumor Virology Javier.R.T et al. Cancer res 2008
Javier, R. T. et al. Cancer Res 2008 Virus 30-40% Human Cancers Timeline of Advances on Tumor Virology