Proximal NaHcO3 Nacl Nacl (+PTH) Distal convoluted convoluted tubule Proximal 6570%Na straight tubule 10%Na+ ca Collecting Glomerulus H2o tubule Cortex 325%N ()NaCl 2~5%Na+ 2C| K H Thick ascending limb HO urine Thi (+ADH) descend limb Collecting concentration duct Thin ascending limb Loop of Henle nner medulla
urine concentration
Pro× mal convoluted tubule(近曲小管) 65-70% Na* reabsorption 60 H2O reabsorption convoluted Interstitium- HCO resorption: carbonic unne tubule anhydrase(CA,碳酸酐酶) NHE3 Organic acid secretory systems K 有机酸分泌系统: HC0+H←H+Hco Metabolites(uric acid) Na H2cO: drugs(most of cephalosporins, loop H. cOz diurects. NSAIDs. most of the b -oec CAS-L CA inhibitor lactams thiazide diuretics, most of the Acetazolamide sulfonamides, Acetazolamide(乙酰唑胺 H2+c02 CO?+H-O 乙酰唑胺 rganic bo O ase secretory systems 有机碱分泌系统: Base" Metabolites(choline) drugs(H2 receptor blocker Amiloride阿呵米洛利 ephedrin嘛麻黄碱) morphine, quinine)
Proximal convoluted tubule(近曲小管) 65-70% Na+ 60 % H2O HCO3 - resorption: carbonic anhydrase (CA，碳酸酐酶) Organic acid secretory systems 有机酸分泌系统 : Metabolites (uric acid), drugs (most of cephalosporins, loop diurects, NSAIDs, most of the blactams, thiazide diuretics, most of the sulfonamides, Acetazolamide(乙酰唑胺) Organic base secretory systems 有机碱分泌系统: Metabolites (choline), drugs (H2 receptor blocker, morphine, quinine ) CA inhibitor Acetazolamide 乙酰唑胺 ㈠
Chick ascending limb of henle's loop (髓袢升支粗段) 25% Na* reabsorption Thick 25% Ca* reabsorption Lumen ascending limb terser um > 50-60%Mg2+ reabsorption urine blood NKCC2 Water is impermeable due to N lack of AQP水通道蛋白 ATP K oop diuretics (袢利尿药) (+)Potential+K Mg-. Caz Cation resorption 阳离子重吸收
Thick ascending limb of henle ’s loop （髓袢升支粗段） Ø 25% Na+ a+ Ø 50-60% Mg2+ Ø Water is impermeable due to lack of AQP水通道蛋白 Loop diuretics （袢利尿药） ㈠ Cation resorption 阳离子重吸收 13
vIsta| convoluted tubule(远曲小管) D stal >10%Na* reabsorption Lumen- convoluted tubule erst um- Water impermeable urne blood NCC ATP thyroid hormone Thiazide diuretics (PTH甲状旁 腺激素) (噻嗪类利尿药) Ca-- ATP
Distal convoluted tubule(远曲小管) Ø10% Na+ ØWater impermeable Thiazide diuretics （噻嗪类利尿药） parathyroid hormone （PTH,甲状旁 腺激素） ⊕ ㈠ 14
electing tubule and duct(集合管) Lumen- Collecting Interstitium. > 2-5% Na+ reabsorption unne tubule b ood > Principal cells((主细胞):the ma jor sites of na K+, and Pnncipal cell H2O transportation(Na+ Cl ENaC Aldosteron 重吸收,K分泌) Na? Intercalated cells(闰细胞): the primary sites of proton ATP K secretion(H分泌,少量K+重 吸收) Intercalated cell Potassium-retaining diuretics HC03- (保钾利尿药) AIr H
Collecting tubule and duct（集合管） Ø 2-5% Na+ Ø Principal cells(主细胞) : the major sites of Na+ , K+ , and H2O transportation（Na+ 、Cl - 重吸收，K+分泌） Ø Intercalated cells( 闰细胞) : the primary sites of proton secretion（H+分泌，少量K+重 吸收） Potassium-retaining diuretics （保钾利尿药） ㈠