动脉粥样硬化的形成和发展 伴随一生的风险 泡沫细胞 脂纹 中期损伤 粥样硬化纤维斑块 复合性病变/破裂 内皮功能失调 10岁开始 30岁开始 40岁开始 平滑肌细胞 脂质沉积为主 和胶原 血栓出血 Second Clinical Medical College of Pepine CJ.Am J Cardiol.1998;82(suppl 10A):23S-27S. Southern Medical University
Second Clinical Medical College of Southern Medical University 动脉粥样硬化的形成和发展 伴随一生的风险 泡沫细胞 脂纹 中期损伤 粥样硬化 纤维斑块 复合性病变/破裂 内皮功能失调 10岁开始 30岁开始 40岁开始 脂质沉积为主 平滑肌细胞 和胶原 血栓出血 Pepine CJ. Am J Cardiol. 1998;82(suppl 10A):23S-27S
纤维斑块 脂纹 粥样斑块 Second C 图9-2主动脉粥样硬化 主动脉内膜表面可见隆起的脂纹、纤维斑块 Southerr
Second Clinical Medical College of Southern Medical University 粥样斑块 脂纹
同4学示口一么性使W少江一了回 ★★ Second Clinical Medical College of Southern Medical University
Second Clinical Medical College of Southern Medical University
Hyperlipidemia.Hypertension Smoking,Toxins,Hemodynamic factors,Immune reactions.Viruses Endothelial Injury/Dysfunction Monocyte adhesion and Migration of smooth Cholesterol efflux via HDL emigration into intima muscle cell precursors umen- Extracellular matrix synthesis LDL Macrophage Endothelium Proliferation of LDL (Lipid smooth muscle Cytokines uptake cells (e.g..IL-1.MCP-1) ntima Oxidized LDL Cytokines/Growth Factors Extracellular lipids and necrotic cells nternal Migration of elastic- smooth muscle membrane cells Media Smooth muscle cells Normal vessel Progressive development of artherosclerotic plaque Elsevier.Kumar et al:Robbins Basic Pathology 8e-www.studentconsult.com
Second Clinical Medical College of Southern Medical University
Vascular endothelium modification In atherosclerosis Blood Monocyte Adhesion molecules Endothelial cell Activation of Macrophage endothelial cell Permeability Free radicals tokines Adhesion Vasodilation Smooth muscle cells Second Clinical Medical College of Southern Medical University
Second Clinical Medical College of Southern Medical University