Bacteriostaticdrugs: The agents can arrest the growth orreplication of the microorganismBactericidal drugsThe agents can kill the microorganisms
Bacteriostatic drugs • The agents can arrest the growth or replication of the microorganism. Bactericidal drugs • The agents can kill the microorganisms
Minimal inhibitory concentration(MIC): MIC is the lowest concentration ofantimicrobial agents that prevents visiblegrowth in 18-24 hours incubation.Minimal bactericidal concentrationn(MBC): MBC is the lowest concentration ofantimicrobial agents that kills bacteria inculture medium
Minimal inhibitory concentration (MIC) • MIC is the lowest concentration of antimicrobial agents that prevents visible growth in 18-24 hours incubation. Minimal bactericidal concentration (MBC) • MBC is the lowest concentration of antimicrobial agents that kills bacteria in culture medium
Chemotherapeutic index (CI).CIis a term used to evaluate thesafety of chemotherapeutic drugsLD50/ED50 orThe value isLD5/ED95
Chemotherapeutic index (CI) •CI is a term used to evaluate the safety of chemotherapeutic drugs. • The value is LD50/ED50 or LD5/ED95
Post - antibiotic effect, PAE·PAEshows the antimicrobialeffect after the concentrationdecreased below MIC
Post - antibiotic effect , PAE •PAE shows the antimicrobial effect after the concentration decreased below MIC
Il. Selection of antimicrobial agents(a) the organism's identity and its sensitivity to aparticular agent(b)the siteof the infection(C) the safety of the agent(d) patient factors(e) the cost of therapy
II. Selection of antimicrobial agents (a) the organism’s identity and its sensitivity to a particular agent (b) the site of the infection (c) the safety of the agent (d) patient factors (e) the cost of therapy