Noradrenaline synthesize and elimination8：MAODFDADH28THDDDADDuptakelEdopaTHItyrosineMAO COMTuptake2TH tyrosine hydroxylaseNADDdopa decarboxylaseDHdoparrinebeta-hydroxylase
Noradrenaline synthesize and elimination
Adrenomimetic drugsadrenoceptoragonistsindividuality1 structure: different substituted groupsdifferent of receptor selectivity3 different effects mostly on the systolicand diastolic blood pressure (pulsepressure
Adrenomimetic drugs adrenoceptor agonists ⚫ individuality 1 structure: different substituted groups 2 different of receptor selectivity 3 different effects mostly on the systolic and diastolic blood pressure (pulse pressure)
aβreceptoragonist肾上腺素AdAdrenalineEEpinephrineRooted in adrenal gland medulla, instabilityPharmacokinetics:absorption : is poor with oral administration sc ori.minjection.distrbution: the area of noradrenergic nervedomination;elimilation: uptake, orinactivation by MAOCOMT
αβreceptor agonist Adrenaline Ad 肾上腺素 Epinephrine E ⚫ Rooted in adrenal gland medulla，instability ⚫ Pharmacokinetics： absorption : is poor with oral administration ， sc or i.m injection . distrbution: the area of noradrenergic nerve domination； elimilation: uptake，or inactivation by MAO, COMT
aβreceptoragonist--adrenalineEffectsa very potentaβreceptor agitated action1 heart: β,receptorexcitement2 blood vessels: a, and β, receptorskin vessels, mucous membrane vessels.viscus vesselscontraction;brain,pulmonarybloodvesselsfeeble vasoconstriction;skeletal muscle vessels ,coronary arterydilation
αβreceptor agonist -adrenaline Effects a very potentαβreceptor agitated action 1 heart : β1 receptor excitement 2 blood vessels: α1 and β2 receptor skin vessels, mucous membrane vessels, viscus vessels contraction； brain, pulmonary blood vessels feeble vasoconstriction; skeletal muscle vessels ,coronary artery dilation
aβreceptor agonist --adrenalineβ2 receptor agitateblood pressurecoronaryarteryfluxperfusion pressureadenosineincrease3bloodpressuresystolic blood pressure increase,diastolic pressure steadiness or slightlyfallpulse pressure
αβreceptor agonist - adrenaline β2 receptor agitate blood pressure coronary artery perfusion pressure flux adenosine increase ⚫ 3 blood pressure systolic blood pressure increase, diastolic pressure steadiness or slightly fall pulse pressure