Gene ofinterestβ-LactoglobulinTransgenic sheep as apromoterbiofactoryValuableproducts areDNAis injectedintopronucleus.produced in the milkHoldingSheepovumpipetteImplantintofostermother.TransgenicprogenyareidentifiedbyPCRExpressionofgeneofinterestisrestrictedtomammarytissue
9-16 Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Transgenic sheep as a Transgenic sheep as a biofactory biofactory Valuable products are Valuable products are produced in the milk. produced in the milk
TABLE22.1Examplesof Genetically EngineeredBiopharmaceuticalProductsAvailableor underDevelopmentGene ProductCondition TreatedHostTypeAnemiaErythropoitinE.coli,cultured mammalian cellsMultiplesclerosis,cancerInterferonsE.coli,cultured mammaliancellsTissue plasminogen activator tPAHeartattack,strokeCulturedmammaliancellsHuman growth hormoneDwarfismCulturedmammalian cellsMonoclonalantibodiesagainstvascularCancersCultured mammaliancellsendothelialgrowthfactor(VEGF)Hemophilia ATransgenic sheep, pigsHuman clottingfactorVillC1inhibitorHereditaryangioedemaTransgenic rabbitsRecombinant human antithrombinHereditary antithrombin deficiencyTransgenicgoatsHepatitisBsurfaceproteinvaccineCulturedyeastcells,bananasHepatitis B infectionsImmunoglobulinIgG1to HSV-2Transgenic soybeans glycoprotein BHerpesvirusinfectionsRecombinantmonoclonalantibodiesPassiveimmunizationagainstrabies(alsousedinTransgenictobacco,soybeans,cultured mammaliancellsdiagnosingrabies),cancer,rheumatoidarthritisNorwalk virus capsid proteinNorwalkvirus infectionsPotato (ediblevaccine)E.coli heat-labile enterotoxinE.coli infectionsPotato (ediblevaccine)9-17
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