Chapter 19B Systems Biology and the Future of Medicine 12-1
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Sections to study1. What is systems biology?2.Biology as an informational science3.The practice of systems biology4.A systems approach to disease5.Syntheticbiology12-2
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 12-2 Sections to study Sections to study 1. What is systems biology? 1. What is systems biology? 2. Biology as an informational science 2. Biology as an informational science 3. The practice of systems biology 3. The practice of systems biology 4. A systems approach to disease 4. A systems approach to disease 5. Synthetic biology 5. Synthetic biology
1. What is systems biology?Thehuman immune systemNatural ImmunityMoreeffectivephagoctosisandeliminationofNonSelfMacrophages & NeutrophilsK1Non Self(Foreign,materials)AntitbodiesLymplinokinesPmysical BarriersTLymphocytesB Lymphocytesarane&mucusmeprevententoyCelutarHumoralImmunityImmunitySknChamicai Barrierspt,aoanetonu,eto.Non Self cs annautrelizeopalantigenic stimulus7Cellular Barriersneubrophila,rnecrophagesAcquired Immunitynetural kllkar oalle12-3
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 12-3 1. What is systems biology? 1. What is systems biology? The human immune system
Wehave known the human immune system so well, but we arestill unable to develop vaccines against every infectious disease.Why?12-4
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 12-4 We have known the human immune system so well, but we are still unable to develop vaccines against every infectious disease. Why?
We do not understand the immune system's two mostfundamental properties:immunity and tolerance.Immunologists have studied the components of the immune system onegene and one protein at a time, but not them all together as a systemImmuneProtectionand ToleranceDefence againstimicrobial infectionsStrongThi immunity:IFN-ymacrophages CTLTh1Th2Pregnancy --tolerance to non-self-MHC-fetusandspermDominanceof Th2immunity:IL-1o,TGF-βsusceptible to infections,less autoimmunity12-5
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 12-5 We do not understand the immune system We do not understand the immune system’s two most s two most fundamental properties: fundamental properties: immunity immunity and tolerance tolerance. Immunologists have studied the components of the immune system o Immunologists have studied the components of the immune system one gene and one protein at a time, but not them all together as a s gene and one protein at a time, but not them all together as a system