Chapter 12 Chromosomal Rearrangements and Changes in Chromosome Number 14-1
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Sectionsto study12.1Rearrangements of chromosomalDNA12.2The effects of rearrangements12.3Transposablegeneticelements12.4 Aberrations in chromosome number: Aneuploidy12.5 Variation in number of chromosome sets:Euploidy12.6 Genome reconstructing and evolution14-2
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 14-2 Sections to study Sections to study 12.1 Rearrangements of chromosomal DNA 12.1 Rearrangements of chromosomal DNA 12.2 The effects of rearrangements 12.2 The effects of rearrangements 12.3 Transposable genetic elements 12.3 Transposable genetic elements 12.4 Aberrations in chromosome number: 12.4 Aberrations in chromosome number: Aneuploidy Aneuploidy 12.5 Variation in number of chromosome sets: 12.5 Variation in number of chromosome sets: Euploidy Euploidy 12.6 Genome reconstructing and evolution 12.6 Genome reconstructing and evolution
Twotypes ofevents that reshapegenomesChromosomal rearrangementsRearrangements of DNA seguences within one or more chromosomes.Changes in chromosome numberLosses orgainsofchromosomes or setsofchromosomes.Significance:Forces thatdrivethe evolution of new speciesChromosome rearrangementGenomeduplication14-3
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 14-3 Two types of events that reshape genomes Chromosomal rearrangements Chromosomal rearrangements Rearrangements of DNA sequences Rearrangements of DNA sequences within one or more chromosomes. within one or more chromosomes. Changes in chromosome number Changes in chromosome number Losses or gains of chromosomes or sets of chromosomes. Losses or gains of chromosomes or sets of chromosomes. Forces that drive the evolution of new species Forces that drive the evolution of new species Chromosome rearrangement Chromosome rearrangement Genome duplication Genome duplication Significance:
12.1RearrangementsofchromosomalDNATABLE12.1MajorClasses of ChromosomalRearrangementsLettersrepresentlargechromosomalregions.Different(nonhomologous)chromosomesareindicatedasredandblueNormalRearrangedDeletionCADEIFGHDuplicationABCDEFGHABCBCDEIEICHInversionACBDIEFGH180°rotationTranslocationABCDEFGHLMNOEFGHLIMNIOPQRABCDIPQR14-4
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Chromosome breakage and subseguent DNA repair can result inallclassesofchromosomalrearrangements.DDeletionaLossDCB(b)InversionaDeletion(c)CDDuplicationH(d)TranslocationFig12.214-5
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 14-5 Fig 12.2 Chromosome breakage and subsequent DNA repair can result in Chromosome breakage and subsequent DNA repair can result in all classes of chromosomal rearrangements. all classes of chromosomal rearrangements