Chapter 7 Anatomy and Function of a Gene: Dissection Through Mutation 7-1
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Sections to study7.1 Mutations: Primary tools of genetic analysisWhere do mutations come from?DNAdamagerepair7.2What mutations tell us aboutgene structure?7.3 What mutations tell us about gene function?7.4 A comprenensive exampie:Miutationstnataffectvision7-2
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 7-2 Sections to study Sections to study 7.1 Mutations: Primary tools of genetic analysis 7.1 Mutations: Primary tools of genetic analysis Where do mutations come from? Where do mutations come from? DNA damage repair DNA damage repair 7.2 What mutations tell us about gene structure? 7.2 What mutations tell us about gene structure? 7.3 What mutations tell us about gene function? 7.3 What mutations tell us about gene function? 7.4 A comprehensive example: Mutations that affect 7.4 A comprehensive example: Mutations that affect vision
Alternative forms of genes help trackinggenes in crossesRoundorwrinkledripeseedsYelloworgreenseedinteriorsGreenoryellowunripepodsPurpleorwhitepetalsAxialorterminalflowersLongorshortstemsInflatedorpinchedripepods7-3
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 7-3 Alternative forms of genes help tracking Alternative forms of genes help tracking genes in crosses genes in crosses
Wild-type allele: Anallele with a frequencyof morethan1%inapopulationMutant allele:Lessthan 1% in apopulation
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 7-4 Wild-type allele type allele: An allele with a frequency allele with a frequency of more than 1% in a of more than 1% in a population. population. Mutant allele Mutant allele: Less than 1% in a than 1% in a population. population
7.1Mutations:Primary tools of genetic analysisMutations are heritable changes in DNA seguences.Forward mutation - changes wild-type to a different allele.Reverse mutation (reversion)- causes mutation to revert backto wild-type.7-5
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 7-5 Mutations Mutations are heritable changes in DNA sequences. are heritable changes in DNA sequences. Forward mutation Forward mutation – changes wild changes wild-type to a different allele. type to a different allele. Reverse mutation Reverse mutation (reversion) (reversion)– causes mutation to revert back causes mutation to revert back to wild to wild-type. 7.1 Mutations: Primary tools of genetic analysis 7.1 Mutations: Primary tools of genetic analysis