Chapter10Analyzing genomic variation11-1
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Sectionsto study10.1 Variation among individual genomes10.2 Four classes of DNA polymorphisms10.4 Positional cloning -Use of polymorphic DNA markers toclonedisease-causinggenes11-2
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 11-2 Sections to study Sections to study 10.1 Variation among individual genomes 10.1 Variation among individual genomes 10.2 Four classes of DNA polymorphisms 10.2 Four classes of DNA polymorphisms 10.4 Positional cloning 10.4 Positional cloning – Use of polymorphic DNA markers to Use of polymorphic DNA markers to clone disease clone disease-causing genes causing genes
10.1 Variation amongindividualgenomesChromosomeomatid ChromatidhatureTlomnreCentromereolomareCellNAdoubinhalMDA0O2001AmeficanAaaocisfionlortheAdvan
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James WatsonJ.CraigVenter(Genome published2007-02)(Gen0mepublished2007-09)116.800K117M116.750K116.850K116.900K116.950K117.050KWatsonVenterAllSNPs干Genes十ASZ1WNT2CFTRSNP variation in a region onchromosome7Fig.10.511-4
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 11-4 J. Craig Venter (Genome published 2007-09) James Watson (Genome published 2007-02) Fig. 10.5 SNP variation in a region on chromosome 7
JamesWatsonJ.CraigVenterYH(a)(b)YH978.3702443435,493509,17591710801,151,0592622924,3331,096,87323742641564,716976VenterWatsonVenterWatsonSingle nucleotide substitutionsAmino acid-changing substitutionsFigure11.211-5
Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 11-5 J. Craig Venter James Watson Figure 11.2 Single nucleotide substitutions Amino acid-changing substitutions