PROGRESSION OF OSTEOLYSIS HYLAMER”CUP Image removed due to copyright considerations
PROGRESSION OF OSTEOLYSIS: “HYLAMER” CUP Image removed due to copyright considerations. Image removed due to copyright considerations
Why artificial Joints Fail Image removed due to copyright considerations Spice, Byron "Particle Disease Seen As Plague on Total Joint Replacement Pittsburgh Post-Gazette
Why Artificial Joints Fail Image removed due to copyright considerations Image removed due to copyright considerations Spice, Byron. “Particle Disease Seen As Plague on Total Joint Replacement” Pittsburgh Post-Gazette
J Charnley, 1979 Photo removed due to copyright considerations
J. Charnley, 1979 Photo removed due to copyright considerations Photo removed due to copyright considerations
MACROPHAGE RESPONSE TO PARTICLES PROSTHESIS WEAR Osteoblasts Particles Bone resorption (Osteolysis BONE Enzymes PgE IL-1 Macrophage Chemoattractants Osteoclast (15-25μm) Osteoclast precursor cells
PROSTHESIS WEAR PROSTHESIS WEAR Particles Particles Bone Resorption Bone Resorption (Osteolysis) (Osteolysis) Macrophage Macrophage (15 -25 µm) IL - 1 PGE 2 Enzymes Enzymes Chemoattractants Chemoattractants MACROPHAGE RESPONSE MACROPHAGE RESPONSE TO PARTICLES TO PARTICLES BONE Osteoclast Osteoclast precursor cells precursor cells Osteoclast Osteoclast Osteoblasts Osteoblasts
POLYETHYLENE WEAR PARTICLES H McKellop, 1994 Hip Society The number of particles generated by a hip prosthesis 7x 10 particles/yr 700,000 particles/step
POLYETHYLENE WEAR POLYETHYLENE WEAR PARTICLES PARTICLES H. McKellop McKellop, 1994 Hip Society , 1994 Hip Society The number of particles generated by a hip The number of particles generated by a hip prosthesis prosthesis 7 x 1011 particles/yr. particles/yr. 700,000 particles/step 700,000 particles/step