N-Acetyl- (N-Acetylmuramic (N-Acetyl Lysozyme target 6 CH2OH CHOH CH2OH CH-cO NH-COCH, H NH-COCH. H NH-COCH H NH一coCH3 L-Alanine L-Alanine D-Isoglutamine Where D-Alanine(o-COOH) D-Alanine(a-COOH lysozyme exits? [Glyls GIcNAc D-I-Glu-N D-1-GIU-N L-Lys D-Ala [GliS Fig.2-16 D-I-GIu-N D-I-GIu-N [GliS [GliS Brooks GF, Carroll KC, Bu Morse SA, Mietzner TA: Jawetz, Melnick, Adeberg's
Fig. 2-16 Lysozyme target Where lysozyme exits? 16
Pentapeptide(vary from species) Lys-type peptidoglycan(group A3 DAP-type peptidoglycan(mDpm-direcn) G G PGRR-LC recognition structure M G PGRP-SA recognition structure G: GIcNAC M: MurNAc G- Peptidoglycan Gt Peptidoglycan meso-diaminopimelic acid m-Dpm Peptidoglycan recognition protein, PGRP
G- Peptidoglycan G+ Peptidoglycan Peptidoglycan recognition protein, PGRP Pentapeptide (vary from species) meso-diaminopimelic acid m-Dpm 17
GRAM POSITIVE CELL WALL Special components: Teichoic acid TA Teichoic acid (WTA wall associated) Lipoteichoic acid (LTA, membrane associated -Negatively charged Surface antigen attachment of bacteria to animal cells Lipoteichoic acid Peptidoglycan-teichoic acid Peptidoglycan ③恐 Cytoplasmic membrane Figure 2-16 p 24 Cytoplasm 18
Cytoplasm Cytoplasmic membrane GRAM POSITIVE CELL WALL Special components: Teichoic acid TA Teichoic acid (WTA wall associated) Lipoteichoic acid (LTA, membrane associated) -Negatively charged -Surface antigen, attachment of bacteria to animal cells Lipoteichoic acid Peptidoglycan-teichoic acid Peptidoglycan Figure 2-16 p.24 18