Dopamin receptor: two type, five subtype DAl D1-like receptor ): D1, D5 DA2 D2-like receptor) D2, D3, D4
◼ Dopamin receptor: two type, five subtype - DA1 (D1-like receptor): D1,D5 - DA2 (D2-like receptor): D2,D3, D4
D2 like receptors(D2 D3, D4) Activate gi→cAMP Block Ca++ channels Open K+ channels D2: putamen(壳核), olfactory tubercle (嗅结节) D3 frontal cortex, medulla midbrain D4;???
◼ D2 like receptors (D2, D3, D4) ◼ Activate Gi → cAMP ◼ Block Ca++ channels ◼ Open K+ channels ◼ D2: putamen(壳核）, olfactory tubercle （嗅结节） ◼ D3: frontal cortex, medulla, midbrain ◼ D4: ???
a D2 receptor activation >T motor activity aggravates schizophrenia D2 receptor blockade >alleviation of schizopnrenia
◼ D2 receptor activation → motor activity → aggravates schizophrenia ◼ D2 receptor blockade → alleviation of schizophrenia