Antidiabetic Drugs-Insulin and Oral Antisiabetis Drugs Department of Pharmacology Liming zhou Emailzhou108a163.com 2018.10
Antidiabetis Drugs－Insulin and Oral Antisiabetis Drugs Department of Pharmacology Liming zhou Email: zhou108@163.com 2018.10
Overview a diabetes mellitus a chronic condition associated with abnormally high blood sugar Results from either deficiency of or a resistance to insulin-a hormone produced by the pancreas whose function is to lower blood sugar
Overview ◼ diabetes mellitus A chronic condition associated with abnormally high blood sugar. Results from either deficiency of or a resistance to insulin- a hormone produced by the pancreas whose function is to lower blood sugar
Overview a morbidity 300,000 people-→>0.67% 40 years old-→2.53 >19942564 years old-→2.51% 19962075 years old-→3.21% 1997-→13,500,000 people (all over the word ■2015全球糖尿病成年患者达4.15亿,中国占 1.1亿
Overview ◼ morbidity： ➢ 300,000 people－→>0.67％ ➢ 40 years old―→2.53％ ➢ 1994 25~64 years old－→2.51％ ➢ 1996 20~75 years old－→3.21％ ➢ 1997―→13,500,000 people (all over the word) ◼ 2015全球糖尿病成年患者达4.15亿, 中国占 1.1亿
Overview Cause by many of reasons -chronic hyperglycemia → metabolic disorder a Hyperglycemia --a group of diseases characterized by high levels of blood glucose resulting from defects in insulin production, insulin action, or both ■ Insulin: B cells=- - synthesis=→丶 secretion-- blood circulation -target cells--binding with insulin receptor --intracellular substance metabolism a any link going wrong -diabetes mellitus
Overview ◼ Cause by many of reasons ――chronic hyperglycemia －→metabolic disorder ◼ Hyperglycemia ―― a group of diseases characterized by high levels of blood glucose resulting from defects in insulin production, insulin action, or both. ◼ Insulin: B cells ――synthesis－→secretion ――blood circulation－→target cells－→binding with insulin receptor －→intracellular substance metabolism ◼ any link going wrong －→diabetes mellitus
Overview Diabetes mellitus --long-term disease multisystem damage --functional defect and failure Severe --dia betic ketoacidosis --coma a Etiopathogenisis --heredity, autoimmunity, environmental factor a Diagnosis blood glucose
Overview ◼ Diabetes Mellitus ――long-term disease ――multisystem damage－→functional defect and failure ◼ Severe－→diabetic ketoacidosis－→coma ◼ Etiopathogenisis ――heredity, autoimmunity, environmental factor ◼ Diagnosis：blood glucose