Classification of antipsychotic drugs Phenenothiazines(吩噻嗪类) (Chlorpromazine) a Thioxanthenes(硫杂蒽类) (Tardan, flupenthixol Butyrophenones(丁酰苯类) (Haloperidol) Atypicals)(非典型药物) Clozapine)
Classification of antipsychotic drugs ◼ Phenenothiazines（吩噻嗪类) (Chlorpromazine) ◼ Thioxanthenes(硫杂蒽类） (Tardan,flupenthixol) ◼ Butyrophenones（丁酰苯类） (Haloperidol) ◼ Atypicals )( 非 典 型 药 物 ） (Clozapine)
Chlorpromazine(wintermine Pharmaciolgical effects CNS effects 1.neuroleptic effect hallucination and delusions(错觉) improvement
Chlorpromazine (wintermine) ◼ Pharmaciolgical effects ◼ CNS effects 1.neuroleptic effect: hallucination and delusions（错觉） improvement
Mechanism of action Blockade dopaminergic neurotransmission the limbic nigrostriatal hypothalamic system
Mechanism of action Blockade dopaminergic neurotransmission -the limbic - nigrostriatal - hypothalamic system
Dopamine Hypothesis. This idea was suggested by observation that drugs which reduced dopaminergic activity reduced acute symptoms/signs of psychoses. Symptoms notably Decreased 口 agitation ty a hallucinations
Dopamine Hypothesis: This idea was suggested by observation that drugs which reduced dopaminergic activity reduced acute symptoms/signs of psychoses. ◼ Symptoms notably Decreased -- agitation anxiety hallucinations
Four pathway of dopaminergic neurotransmission 1Mesolimbic-mesocortical pathway (one most closely related to behavior nigrostriatal pathwaylit is involved in the coordination of voluntary movement 3tuberoinfundibular pathway (inhibits prolactin secreation) 4) medullary-periventricular pathway (the function is not clear may be involved eating behavior)
Four pathway of dopaminergic neurotransmission ◼ 1)Mesolimbic-mesocortical pathway (one most closely related to behavior ) ◼ 2)nigrostriatal pathway(it is involved in the coordination of voluntary movement) ◼ 3)tuberoinfundibular pathway (inhibits prolactin secreation) ◼ 4 ） medullary-periventricular pathway (the function is not clear ,may be involved eating behavior)