Chapter 49 Antineoplastic Drugs Department of pharmacology Liu xiaokang(刘小康) 2010.3
Chapter 49 Antineoplastic Drugs Department of pharmacology Liu xiaokang(刘小康） 2010,3
Categories 1) Antimetabolites: a) Folic Acid Analogs (Methotrexate, MTX). b) Pyrimidine analogs (Fluorouracil, 5-FU; Fluorodeoxyuridine; ytarabine). d) Purine analogs (6 Mercaptopurine, 6-MP; 6-Thioguanine, 6-TG). 2) Alkylating agents: Nitrogen mustards Cyclophosphamide; Thiotepa 3) Natural products: Vinca alkaloids (Vincristine; Vinblastine; Vinorelbine); Paclitaxel axo
Categories: • 1) Antimetabolites: a) Folic Acid Analogs (Methotrexate, MTX). b) Pyrimidine analogs (Fluorouracil, 5-FU; Fluorodeoxyuridine; Cytarabine). d) Purine analogs (6- Mercaptopurine, 6-MP; 6-Thioguanine, 6-TG). • 2) Alkylating agents: Nitrogen mustards; Cyclophosphamide; Thiotepa. • 3) Natural products: Vinca alkaloids (Vincristine; Vinblastine; Vinorelbine); Paclitaxel (Taxol® )
4) Antiumor antibiotics: Anthracyclines oxorubicin hydrochloride, Daunorubicin, Bleomycin 5)Miscellaneous agents: Cisplatin; Carboplatin; Asparaginase; Hydroxyurea Corticosteroid
• 4) Antiumor antibiotics: Anthracyclines (Doxorubicin hydrochloride, Daunorubicin, Bleomycin) • 5) Miscellaneous agents: Cisplatin; Carboplatin; Asparaginase; Hydroxyurea; Corticosteroid
Mechanisms Biological mechanism. (1)Cell cycle: a) Gap 1(G phase). b) DNA Synthesis(S phase). c)Gap2(G2 phase). d) Mitosis (M phase). Go is a resting phase in which the cells are not proliferin
Mechanisms: • Biological mechanism: • (1) Cell cycle: • a) Gap 1 (G1 phase). b) DNA synthesis (S phase). c) Gap 2 (G2 phase). d) Mitosis (M phase). G0 is a resting phase in which the cells are not prolifering
THE CELLCTCLE Beginnin Cell divides of cvcle (mitosis) Cell enlai and makes Cell prepares niew fjrutEirIs to dfid Cell rests R Cell replicates Restriction poin its DNA cell decides whethe to commit itself to the complete cycle