ART TK used to unravel involve of the immune mental conditions. Ho of unknown add ambiguity to the in of lymphocytes quently repea Addition of Expression Profile of Diffuse Large B-cell Lymphoma. plified to the extent that

has declined become the se led only by heart di person in three in the that one in five will die spective, cancer cells ca ch ing particular a Cancerous melanoma cells. nized by the ir d cers Cancer: Origin and Terminology The final section des

immunology, refers to the act of transferring cells, tissues, or organs from one site to another. The desire to accomplish transplants stems from the realization that many diseases can be cured by implantation of a healthy organ, tissue, or cells(a graft)from one individual (the donor)to another in need of the transplant(the recipient or

realized that the immune system could go awry and, instead of reacting against foreign antigens, could focus its attack on self-antigens. He termed this con- dition\horror autotoxicus \We now understand that while mechanisms of self-tolerance normally protect an individual from potentially self-reactive lymphocytes, there are failures They result in an inappropriate response of the immune system against self-components termed autoimmunity In the 1960s, it was believed that all self-reactive lymphocytes

lure can have dire consequences. Nude Mouse (nu/nu) elf and begins to attack hich is Primary Immunodeficiencies AIDS and Other Acquired or Secondary Immunodeficiencies at birth differentiated from immunodeficiencies in which the non- specific mediators of innate immunity, such as phagocytes or ed. Immunodeficiencies are conve- by the type or the developmental stage of overall cellular de g the locations of prevennon stra

the early vaccination trials of Edward Jenner and oneering efforts, vac nce of diseases such ng cougl Vaccination with DN A Active and Passive Immunization Designing Vaccines for Active Immunization mWhole-Organism Vaccines Purified Macromolecules as Vaccines Recombinant-Vector Vaccines DNA Vaccines Multivalent Subunit Vaccines mmon usage. Experience has shown that not every vaccine

susceptible host, a series of coordinated events must rcumvent both innate and adaptive immunity. One of the first and most important features of host innate immunity is the barrier provided by the epithelial surfaces of the skin and the lining of the gut. The difficulty of penetrat- ing these epithelial barriers ensures that most pathogens never gain productive entry into the host. In addition to pro viding a physical barrier to infection, the epithelia also pro duce chemicals that are useful in

effector molecules that act to remove antigen b ren various mechanisms described in previous chap es antigen without A Second Exposure to Poison Oak May Result in Delayed-Type Hypersensitivity Gell and Coombs Classification IgE-Mediated (Type I) Hypersensitivity Antibody-Mediated Cytotoxic(Type) Hypersensitivity aImmune Complex-Mediated (Type Ill) Hypersensitivity

part of the body to another. This is espe- ially true of lymphocytes, which circulate ly in the blood and lymph and, in common with at sites o Lymphocytes Attached to the Surface of a High-Endothelial Venule sLymphocyte Recirculation Cell-Adhesion Molecules Neutrophil Extravasation Lymphocyte Extravasation Chemokines-Key Mediators of Inflammation Other Mediators of Inflammation The Inflammatory Process

ne system assume different roles in pro- the host. The effectors of the humoral molecules f cells Big CTL Attacks Little Tumor Cell Effector Responses General Properties of Effector Cells Cytotoxic T Cells Natural Killer Cells Antibody-Dependent- Cell-Mediated- Cytotoxicity Experimental Assessment of Cell-Mediated Cytotoxicity