上游充通大 SHANGHAI JIAO TONG UNIVERSITY aminoglycosides Mechanism: binding to the $12 Protein of the 30S subunit of the bacterial ribosome,interfering with the binding of formyl-methionyl-tRNA to the 30S subunit
aminoglycosides Mechanism: binding to the S12 Protein of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit
Inhibition of Protein Synthesis by Antibiotics Chloramphenicol Growing peptide binds to 50S r-RNA and inhibits formation of peptide bond 505 D0j01 下-RNA Erythromycin +-RNA binds to 508 r-RNA and prevents movement along m-RNA m-RNA 30S portion Streptomycin Tetracycline changes shape of 30S interfers with the t-RNA r-RNA and causes m-RNA anticodon reading of to be read incorrectly m-RNA codon C.Ophardt.c.2003
上游充通大 Resistance to aminoglycosides SHANGHAI JIAO TONG UNIVERSITY aminoglycoside-modifying enzymes(钝化酶) √Phosphoryltransferases(磷酰转移酶) √Acetyltransferases（乙酰转移酶) √Adenylyltransferases(腺苷酰转移酶)
Resistance to aminoglycosides aminoglycoside-modifying enzymes (钝化酶) ü Phosphoryltransferases（磷酰转移酶） ü Acetyltransferases（乙酰转移酶） ü Adenylyltransferases（腺苷酰转移酶）
上游充通大 SHANGHAI JIAO TONG UNIVERSITY Polymyxins多黏菌素
Polymyxins 多黏菌素
上充通大学 Polymyxins(多粘菌素类) SHANGHAI JIAO TONG UNIVERSITY H N HO Cyclic peptide with a long hydrophobic tail
Polymyxins（多粘菌素类） Cyclic peptide with a long hydrophobic tail